User profiles for "author:D M Salter"
Donald M SalterProfessor of Osteoarticular Pathology Verified email at ed.ac.uk Cited by 16769 |
Integrin-dependent signal cascades in chondrocyte mechanotransduction
SJ Millward-Sadler, DM Salter - Annals of biomedical engineering, 2004 - Springer
Mechanical forces influence chondrocyte metabolism and are critically important for
maintenance of normal cartilage structure and integrity. In cells of the musculoskeletal …
maintenance of normal cartilage structure and integrity. In cells of the musculoskeletal …
Signalling cascades in mechanotransduction: cell–matrix interactions and mechanical loading
Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes
and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical …
and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical …
Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis
Background—The pathophysiology of aortic stenosis is incompletely understood, and the
relative contributions of valvular calcification and inflammation to disease progression are …
relative contributions of valvular calcification and inflammation to disease progression are …
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.
CA Purdie, DJ Harrison, A Peter, L Dobbie, S White… - Oncogene, 1994 - europepmc.org
In human tumourigenesis the tumour suppressor gene most commonly affected by mutation,
inactivation or allele loss is p53. Loss of p53 function is associated both with failure to …
inactivation or allele loss is p53. Loss of p53 function is associated both with failure to …
Integrin-interleukin-4 mechanotransduction pathways in human chondrocytes.
DM Salter, SJ Millward-Sadler, G Nuki… - … and Related Research …, 2001 - journals.lww.com
Mechanical stimuli are known to have major influences on chondrocyte function. The
molecular events that regulate chondrocyte responses to mechanical stimulation are …
molecular events that regulate chondrocyte responses to mechanical stimulation are …
Mechanotransduction via integrins and interleukin‐4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic …
SJ Millward‐Sadler, MO Wright… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To determine molecular events in the regulation of messenger RNA (mRNA) of
cartilage matrix molecules and proteases by mechanical stimulation of chondrocytes from …
cartilage matrix molecules and proteases by mechanical stimulation of chondrocytes from …
Integrin expression in human bone
Integrins are a family of heterodimeric transmembrane glycoproteins that are known to
mediate cell‐cell and cell‐matrix interactions. Members of the VLA (very late activation) …
mediate cell‐cell and cell‐matrix interactions. Members of the VLA (very late activation) …
Integrin-regulated secretion of interleukin 4: a novel pathway of mechanotransduction in human articular chondrocytes
SJ Millward-Sadler, MO Wright, HS Lee… - The Journal of cell …, 1999 - rupress.org
Chondrocyte function is regulated partly by mechanical stimulation. Optimal mechanical
stimulation maintains articular cartilage integrity, whereas abnormal mechanical stimulation …
stimulation maintains articular cartilage integrity, whereas abnormal mechanical stimulation …
Hyperpolarisation of cultured human chondrocytes following cyclical pressure‐induced strain: evidence of a role for α5β1 integrin as a chondrocyte mechanoreceptor
MO Wright, K Nishida, C Bavington… - Journal of …, 1997 - Wiley Online Library
Mechanical stimuli influence chondrocyte metabolism, inducing changes in intracellular
cyclic adenosine monophosphate and proteoglycan production. We have previously …
cyclic adenosine monophosphate and proteoglycan production. We have previously …
Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases
H Monaghan, DM Salter, A Al-Nafussi - Journal of clinical pathology, 2001 - jcp.bmj.com
Aims/Background—Giant cell tumour of the tendon sheath (GCTTS) is regarded as the most
common neoplasm of the hand that can recur after excision. The objective of this study was …
common neoplasm of the hand that can recur after excision. The objective of this study was …