Mechanical forces influence chondrocyte metabolism and are critically important for
maintenance of normal cartilage structure and integrity. In cells of the musculoskeletal …

Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes
and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical …

Background—The pathophysiology of aortic stenosis is incompletely understood, and the
relative contributions of valvular calcification and inflammation to disease progression are …

In human tumourigenesis the tumour suppressor gene most commonly affected by mutation,
inactivation or allele loss is p53. Loss of p53 function is associated both with failure to …

Mechanical stimuli are known to have major influences on chondrocyte function. The
molecular events that regulate chondrocyte responses to mechanical stimulation are …

Objective To determine molecular events in the regulation of messenger RNA (mRNA) of
cartilage matrix molecules and proteases by mechanical stimulation of chondrocytes from …

Integrins are a family of heterodimeric transmembrane glycoproteins that are known to
mediate cell‐cell and cell‐matrix interactions. Members of the VLA (very late activation) …

Chondrocyte function is regulated partly by mechanical stimulation. Optimal mechanical
stimulation maintains articular cartilage integrity, whereas abnormal mechanical stimulation …

Mechanical stimuli influence chondrocyte metabolism, inducing changes in intracellular
cyclic adenosine monophosphate and proteoglycan production. We have previously …

Aims/Background—Giant cell tumour of the tendon sheath (GCTTS) is regarded as the most
common neoplasm of the hand that can recur after excision. The objective of this study was …