User profiles for "author:D T Hughes"

David T Hughes

- Verified email at ucdenver.edu - Cited by 3315

David T Hughes

- Verified email at umich.edu - Cited by 2268

Inter-kingdom signalling: communication between bacteria and their hosts

DT Hughes, V Sperandio - Nature Reviews Microbiology, 2008 - nature.com
Microorganisms and their hosts communicate with each other through an array of hormonal
signals. This cross-kingdom cell-to-cell signalling involves small molecules, such as …

Central neck dissection for papillary thyroid cancer

DT Hughes, GM Doherty - Cancer control, 2011 - journals.sagepub.com
Background Central compartment lymph node dissection is a common adjunct to
thyroidectomy in the treatment of papillary thyroid cancer. The indications, surgical …

The QseC sensor kinase: a bacterial adrenergic receptor

MB Clarke, DT Hughes, C Zhu… - Proceedings of the …, 2006 - National Acad Sciences
Quorum sensing is a cell-to-cell signaling mechanism in which bacteria respond to hormone-
like molecules called autoinducers (AIs). The AI-3 quorum-sensing system is also involved …

Targeting QseC signaling and virulence for antibiotic development

DA Rasko, CG Moreira, DR Li, NC Reading, JM Ritchie… - Science, 2008 - science.org
Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to
respond to host adrenergic signaling molecules and bacterial signals in order to promote the …

The most commonly occurring papillary thyroid cancer in the United States is now a microcarcinoma in a patient older than 45 years

DT Hughes, MR Haymart, BS Miller, PG Gauger… - Thyroid, 2011 - liebertpub.com
Background: The incidence of papillary thyroid cancer (PTC) is growing at a faster rate than
any other malignancy. However, it is unknown what effect age is having on the changing …

Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer

DT Hughes, ML White, BS Miller, PG Gauger… - Surgery, 2010 - Elsevier
BACKGROUND: Prophylactic central lymph node dissection with total thyroidectomy (TT) for
the treatment of papillary thyroid cancer (PTC) is controversial because of the possibility of …

[HTML][HTML] The QseC Adrenergic Signaling Cascade in Enterohemorrhagic E. coli (EHEC)

DT Hughes, MB Clarke, K Yamamoto, DA Rasko… - PLoS …, 2009 - journals.plos.org
The ability to respond to stress is at the core of an organism's survival. The hormones
epinephrine and norepinephrine play a central role in stress responses in mammals, which …

[PDF][PDF] Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration

HL Smith, OJ Freeman, AJ Butcher, S Holmqvist… - Neuron, 2020 - cell.com
Recent interest in astrocyte activation states has raised the fundamental question of how
these cells, normally essential for synapse and neuronal maintenance, become pathogenic …

Chemical sensing in mammalian host–bacterial commensal associations

DT Hughes, DA Terekhova, L Liou… - Proceedings of the …, 2010 - National Acad Sciences
The mammalian gastrointestinal (GI) tract is colonized by a complex consortium of bacterial
species. Bacteria engage in chemical signaling to coordinate population-wide behavior …

A Novel Two-Component Signaling System That Activates Transcription of an Enterohemorrhagic Escherichia coli Effector Involved in Remodeling of Host Actin

NC Reading, AG Torres, MM Kendall… - Journal of …, 2007 - Am Soc Microbiol
ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is responsible for
worldwide outbreaks of bloody diarrhea, hemorrhagic colitis, and life-threatening hemolytic …