Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …

It is recognized that some mutated cancer genes contribute to the development of many
cancer types, whereas others are cancer type specific. For genes that are mutated in …

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

Fracture-related infection (FRI) is one of the most challenging complications in orthopaedic
trauma surgery. It has severe consequences for patients and an important socio-economic …

INTRODUCTION: Odontogenic myxomas are benign but locally invasive tumours originating
from primordial mesenchymal tooth forming tissues which do not metastasise. We present a …

Purpose EURAMOS-1, an international randomized controlled trial, investigated
maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose …

Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity,
which has historically complicated driver gene discovery. Here we sequence exomes of 31 …

Several studies have shown that glypican 3 (GPC3) could be a useful diagnostic marker for
hepatocellular carcinoma (HCC) and for differentiating HCC from nonneoplastic and …

Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to
ionizing radiation or chronic lymphoedema. Previous work has identified aberrant …