User profiles for "author:Debra Higgins"

Debra Higgins

University College Dublin
Verified email at ucd.ie
Cited by 3085

Hypoxia-inducible factor signaling in the development of tissue fibrosis

DF Higgins, K Kimura, M Iwano, VH Haase - Cell cycle, 2008 - Taylor & Francis
Capillary rarefaction is a hallmark of fibrotic diseases and results in reduced blood perfusion
and oxygen delivery. In the kidney, tubulointerstitial fibrosis, which leads to the destruction of …

[HTML][HTML] Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

DF Higgins, K Kimura, WM Bernhardt… - The Journal of …, 2007 - Am Soc Clin Investig
Hypoxia has been proposed as an important microenvironmental factor in the development
of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the …

Hypoxic induction of Ctgf is directly mediated by Hif-1

DF Higgins, MP Biju, Y Akai, A Wutz… - American Journal …, 2004 - journals.physiology.org
CTGF plays a significant role in the development of renal fibrosis by mediating the fibrotic
effects of transforming growth factor (TGF)-β1 and has been shown to be hypoxia inducible …

Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

K Kimura, M Iwano, DF Higgins… - American Journal …, 2008 - journals.physiology.org
Chronic hypoxia accelerates renal fibrosis. The chief mediator of the hypoxic response is
hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1α. HIF-1 …

Future of biomarker evaluation in the realm of artificial intelligence algorithms: application in improved therapeutic stratification of patients with breast and prostate …

J Fitzgerald, D Higgins, CM Vargas, W Watson… - Journal of Clinical …, 2021 - jcp.bmj.com
Clinical workflows in oncology depend on predictive and prognostic biomarkers. However,
the growing number of complex biomarkers contributes to costly and delayed decision …

Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1

EP Brennan, KA Nolan, E Börgeson… - Journal of the …, 2013 - journals.lww.com
Lipoxins, which are endogenously produced lipid mediators, promote the resolution of
inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal …

[HTML][HTML] Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog

NE Kieran, PP Doran, SB Connolly, MC Greenan… - Kidney international, 2003 - Elsevier
Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin
analog. Background Lipoxins are lipoxygenase-derived eicosanoids with anti-inflammatory …

Lipoxin A4 attenuates adipose inflammation

E Börgeson, FC McGillicuddy, KA Harford… - The FASEB …, 2012 - Wiley Online Library
Aging and adiposity are associated with chronic low‐grade inflammation, which underlies
the development of obesity‐associated complications, including type 2 diabetes mellitus …

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

EB Rankin, DF Higgins, JA Walisser… - … and cellular biology, 2005 - Taylor & Francis
Patients with germ line mutations in the VHL tumor suppressor gene are predisposed to the
development of highly vascularized tumors within multiple tissues. Loss of pVHL results in …

Lipoxin A4 and benzo‐lipoxin A4 attenuate experimental renal fibrosis

E Börgeson, NG Docherty, M Murphy… - The FASEB …, 2011 - Wiley Online Library
Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we
investigate the potential of the proresolving eicosanoid lipoxinA4 (LXA4) and its synthetic …