Abstract The PI3K/AKT/mTOR pathway has long been known to play a major role in the
growth and survival of cancer cells. Breast tumors often harbor PIK3CA gene alterations …

Breast cancer (BC) is a common cancer in women worldwide; however, the incidence of BC
is increasing in younger women, possibly associated with the environment. Perfluoroalkyl …

Importance The incidence of brain metastasis is increasing in patients with metastatic breast
cancer. Treatments to extend the control of brain metastasis are urgently required. Objective …

Background Immune checkpoint inhibitors have revolutionized the treatment of
malignancies. However, disproportionate enrollment among races and ethnicities places the …

Background Pseudocirrhosis is an imaging finding of malignancies with liver metastasis with
or without clinical liver cirrhosis-related portal hypertension (pHTN). This study defined …

Aims The ESR1 gene encodes for oestrogen receptor (ER) α, which plays a crucial role in
mammary carcinogenesis and clinical outcome in patients with breast cancer. However, the …

IHC4 and PAM50 assays have been shown to provide additional prognostic information for
patients with early breast cancer. We evaluated whether incorporating TP53 mutation …

Background A rapid surge of female breast cancer has been observed in young women in
several East Asian countries. The BIM deletion polymorphism, which confers cell resistance …

Background This meta-analysis aimed to test the hypothesis that the HER2-positive
metastatic breast cancer (mBC) patients treated with anti-HER2 antibodies in trial …

LBA1068 Background: In Asian countries, BC incidence rates are rising, with a higher
proportion of pre/perimenopausal (pre/peri-M) patients (pts). Data on treatment options for …