Identification of patients with variants in TPMT and dose reduction reduces hematologic events during thiopurine treatment of inflammatory bowel disease

MJH Coenen, DJ de Jong, CJ van Marrewijk… - Gastroenterology, 2015 - Elsevier
Background & Aims More than 20% of patients with inflammatory bowel disease (IBD)
discontinue thiopurine therapy because of severe adverse drug reactions (ADRs); …

Rising incidence and prevalence of primary biliary cirrhosis: a large population‐based study

K Boonstra, AE Kunst, PH Stadhouders… - Liver …, 2014 - Wiley Online Library
Abstract Background & Aims Large population‐based studies are much needed to
accurately establish the epidemiology of primary biliary cirrhosis (PBC). We aimed to collect …

Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions

WJ den Hollander, IL Holster, CM den Hoed… - Gut, 2019 - gut.bmj.com
Objective International guidelines recommend endoscopic surveillance of premalignant
gastric lesions. However, the diagnostic yield and preventive effect require further study. We …

Improvement of gastric inflammation and resolution of epithelial damage one year after eradication of Helicobacter pylori.

EM Witteman, M Mravunac, MJ Becx… - Journal of clinical …, 1995 - jcp.bmj.com
AIMS--To investigate the effect of eradication of Helicobacter pylori infection on gastric
epithelial damage and gastritis, scored according to the Sydney system. METHODS …

Functional dyspepsia

EM Witteman, GNJ Tytgat - The Netherlands journal of medicine, 1995 - Elsevier
Functional dyspepsia is defined as persistent or recurrent upper abdominal pain or
discomfort not explained by structural or biochemical abnormalities. In about half of the …

[HTML][HTML] Factors associated with the progression of gastric intestinal metaplasia: a multicenter, prospective cohort study

SAV Nieuwenburg, MC Mommersteeg… - Endoscopy …, 2021 - thieme-connect.com
Background and study aims Gastric cancer (GC) is usually preceded by premalignant gastric
lesions (GPLs) such as gastric intestinal metaplasia (GIM). Information on risk factors …

Early prediction of thiopurine‐induced hepatotoxicity in inflammatory bowel disease

DR Wong, MJH Coenen, LJJ Derijks… - Alimentary …, 2017 - Wiley Online Library
Background Hepatotoxicity, gastrointestinal complaints and general malaise are common
limiting adverse reactions of azathioprine and mercaptopurine in IBD patients, often related …

Risk factors for primary sclerosing cholangitis

K Boonstra, EMG de Vries, N van Geloven… - Liver …, 2016 - Wiley Online Library
Abstract Background & Aims Primary sclerosing cholangitis (PSC) is a progressive
cholestatic liver disease of unknown cause, but strongly associated with inflammatory bowel …

Increased cancer risk in a large population-based cohort of patients with primary biliary cirrhosis: follow-up for up to 36 years

K Boonstra, R Bokelaar, PH Stadhouders… - Hepatology …, 2014 - Springer
Background and aims The natural history of primary biliary cirrhosis (PBC) has so far mainly
been studied in tertiary referral centres. The aim of the present investigation was to describe …

[HTML][HTML] Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease …

MM Ter Avest, ASM van Velthoven, AEM Speckens… - BMC psychology, 2023 - Springer
Abstract Background Many patients with Inflammatory Bowel Diseases (IBD) suffer from
psychological distress, fatigue and sleep disturbances, which are associated with reduced …