Cardiac tumours are benign or malignant neoplasms arising primarily in the inner lining,
muscle layer, or the surrounding pericardium of the heart. They can be primary or metastatic …

Abstract The Renal Tumour Study Group of the International Society of Paediatric Oncology
(SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood …

Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Abstract The previous International Society of Paediatric Oncology (SIOP) trials and studies
recognized three prognostic groups of renal tumors of childhood: low risk, intermediate risk …

Background Constitutional DICER1 mutations were recently reported to cause familial
pleuropulmonary blastoma (PPB). Aim To investigate the contribution and phenotypic …

On the basis of the results of previous national and international trials and studies, the Renal
Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has …

Purpose: To determine if patients receiving preoperative chemotherapy with vincristine and
actinomycin D for non-metastatic Wilms' tumour have a more advantageous stage …

In the International Society of Paediatric Oncology renal tumour trials, preoperative
chemotherapy has been successfully applied with resulting reduction of tumour rupture and …

Background: Histologic subtypes of standard histology Wilms' tumor (WT) and the effect of
preoperative therapy on their clinical and histologic features, deserve to be analysed in …

Background Before this study started, the standard postoperative chemotherapy regimen for
stage II–III Wilms' tumour pretreated with chemotherapy was to include doxorubicin …