The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic,,,,. Studies of sensory neurons …

The number of people with the insulin-resistant conditions of type 2 diabetes mellitus
(T2DM) and obesity has reached epidemic proportions worldwide. Eighty percent of people …

Leptin, a hormone secreted by adipocytes, plays a pivotal role in the control of body weight.
Rodents with mutations in the leptin receptor gene develop morbid obesity. It is possible …

Var genes encode the major surface antigen (PfEMP1) of the blood stages of the human
malaria parasite Plasmodium falciparum. Differential expression of up to 60 diverse var …

Summary Autoimmune polyendocrinopathy type 1 (APS1) is an autosomal recessive
disorder characterized by autoimmune hypoparathyroidism, autoimmune adrenocortical …

Insulin resistance is characterized by excessive endothelial cell generation of potentially
cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH …

Graves' disease (GD) is an autoimmune thyroid disorder that is inherited as a complex trait.
We have genotyped 77 affected sib-pairs with autoimmune thyroid disease for eight …

Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are
associated with insulin resistance, diabetes, and cardiovascular disease. We investigated …

Although autoimmune Addison's disease (AAD) may occur as a component of the
monogenic autoimmune polyendocrinopathy type 1 syndrome (APS1), it is most commonly …

Coronary heart disease, hypertension, non-insulin-dependent diabetes and obesity are
major causes of ill health in industrial societies. Disturbances of carbohydrate and lipid …