Wound healing is a highly regulated process composed of four overlapping phases:(1)
coagulation/haemostasis,(2) inflammation,(3) proliferation and (4) remodelling …

Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the
maintenance of the skeletal structure and their dramatic role in bone disease were largely …

A severe lack of early diagnosis coupled with resistance to most available therapeutic
options renders pancreatic cancer as a major clinical concern. The limited efficacy of current …

Background Chronic lymphocytic leukemia (CLL) primarily affects older persons who often
have coexisting conditions in addition to disease-related immunosuppression and …

Unique microneedle arrays prepared from crosslinked polymers, which contain no drug
themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to …

Bruton tyrosine kinase (BTK) inhibition is an effective treatment approach for patients with
Waldenström macroglobulinemia (WM). The phase 3 ASPEN study compared the efficacy …

Background Articular cartilage displays a poor repair capacity. The aim of cell-based
therapies for cartilage defects is to repair damaged joint surfaces with a functional …

RESONATE-2 is a phase 3 study of first-line ibrutinib versus chlorambucil in chronic
lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Patients aged≥ 65 years …

We report long-term follow-up from the RESONATE-2 phase 3 study of the once-daily
Bruton's tyrosine kinase inhibitor ibrutinib, which is the only targeted therapy with significant …

We describe, for the first time, hydrogel-forming microneedle arrays prepared from “super
swelling” polymeric compositions. We produced a microneedle formulation with enhanced …