Dobson L, Conway C, Hanley A, Johnson A, Costello S, O'Grady A, Connolly Y, Magee H,
O'Shea D, Jeffers M & Kay E (2010) Histopathology 57, 27–38 Image analysis as an adjunct …

Background and Aims: Trastuzumab provides clinical benefit for advanced and early breast
cancer patients whose tumours over-express or have gene amplification of the HER2 …

Background: The majority of cases of breast cancer scoring HER2 weak positive (2+) on
immunohistochemistry (IHC) using the HercepTest are not associated with amplification of …

Abstract HER2 and TOP2A genes, located on 17q, can be coamplified in cancer.
Overexpression of both genes has been reported in high-grade, androgen-resistant prostate …

For a variety of technical reasons it is rarely possible to study cytogenetic abnormalities in
ductal carcinoma in situ (DCIS) using traditional techniques. However, by combining …

Benign and malignant breast lesions in cytologic preparations can be difficult to distinguish.
The authors applied the silver nucleolar organizer region (AgNOR) technique to cytologic …

We present an X-ray spectral analysis of four solar analogs with different ages and magnetic
activity levels. We find largely different coronal compositions. The most active stars tend to …

Pigmented solar keratosis (PSK) is sometimes clinically indistinguishable from lentigo
maligna, a form of malignant melanoma in situ. Occasionally histologic diagnosis is also …

Because of the relative rarity of ductal carcinoma in situ (DCIS) in the premammographic
screening era, the unavailability of adequate fresh tissue for culture, and the lack of …

The authors studied the retention/loss of immunoreactivity in frozen tissue over a period of 8
weeks using a variety of storage strategies. Ki67 immunoreactivity is com monly used to …