Ovarian cancer is characterize by few early symptoms, presentation at an advanced stage,
and poor survival. As a result, it is the most frequent cause of death from gynecological …

Background Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5
years. We designed this trial to establish the effect of early detection by screening on ovarian …

Early detection remains the most promising approach to improve long-term survival of
patients with ovarian cancer. In a five-center case-control study, serum proteomic …

Background Ovarian cancer continues to have a poor prognosis with the majority of women
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …

Polycomb group proteins (PCGs) are involved in repression of genes that are required for
stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) …

There has been growing interest in the possibility of screening for ovarian cancer. This
article addresses papers published following a systematic review of all prospective ovarian …

Background The value of screening for ovarian cancer is uncertain. We did a pilot
randomised trial to assess multimodal screening with sequential CA 125 antigen and …

Separation of the single anterior foregut tube into the esophagus and trachea involves cell
proliferation and differentiation, as well as dynamic changes in cell–cell adhesion and …

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy,
responsible for 13 000 deaths per year in the United States. Risk prediction based on …

Epithelial ovarian cancer has a major heritable component, but the known susceptibility
genes explain less than half the excess familial risk. We performed a genome-wide …