Antioxidants in health and disease

IS Young, JV Woodside - Journal of clinical pathology, 2001 - jcp.bmj.com
Free radical production occurs continuously in all cells as part of normal cellular function.
However, excess free radical production originating from endogenous or exogenous …

Protecting-group-free synthesis as an opportunity for invention

IS Young, PS Baran - Nature chemistry, 2009 - nature.com
The constant pressure to prepare compounds in a more efficient manner has placed the
process by which traditional synthetic chemistry is conducted under scrutiny. Areas that have …

Lipoprotein oxidation and atherosclerosis

IS Young, J McEneny - Biochemical society transactions, 2001 - portlandpress.com
Lipoprotein oxidation is a key early stage in the development of atherosclerosis. Oxidation of
lowdensity lipoprotein (LDL) is initiated by both enzyme-mediated and non-enzymic …

Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men

SEM Lewis, ESL Sterling, IS Young, W Thompson - Fertility and sterility, 1997 - Elsevier
OBJECTIVE:: To measure individual antioxidants in sperm and seminal plasma from fertile
and infertile men to determine if any particular antioxidant is reduced in infertile men …

Total antioxidant capacity of seminal plasma is different in fertile and infertile men

SEM Lewis, PM Boyle, KA McKinney, IS Young… - Fertility and sterility, 1995 - Elsevier
Objective To determine if the total antioxidant capacity of seminal plasma is different in fertile
and infertile men. Design An enhanced chemiluminescence assay applied to seminal …

Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)

CA Augood, JR Vingerling, PTVM De Jong… - Archives of …, 2006 - jamanetwork.com
Objective To estimate the prevalence of age-related maculopathy in an older population
from 7 European countries. Methods Randomly sampled people 65 years and older were …

The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations

DJ Gaughan, LAJ Kluijtmans, S Barbaux, D McMaster… - Atherosclerosis, 2001 - Elsevier
Epidemiological evidence has revealed that an elevated plasma homocysteine level (
hyperhomocysteinemia) confers an increased risk of cardiovascular disease and neural …

Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T

CJ McCann, BM Glover, IBA Menown… - European heart …, 2008 - academic.oup.com
Aims To evaluate the role of novel biomarkers in early detection of acute myocardial
infarction (MI) in patients admitted with acute chest pain. Methods and results A prospective …

Obesity and the lung: 1· Epidemiology

KM McClean, F Kee, IS Young, JS Elborn - Thorax, 2008 - thorax.bmj.com
Obesity is the most common metabolic disease in the world and its prevalence has been
increasing over several decades. The World Health Organization (WHO) predicts that, by …

Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise

T Ashton, CC Rowlands, E Jones, IS Young… - European journal of …, 1998 - Springer
Free radicals or oxidants are continuously produced in the body as a consequence of
normal energy metabolism. The concentration of free radicals, together with lipid …