Diagnostic concordance and discordance in digital pathology: a systematic review and meta-analysis

AS Azam, IM Miligy, PKU Kimani, H Maqbool… - Journal of Clinical …, 2021 - jcp.bmj.com
Background Digital pathology (DP) has the potential to fundamentally change the way that
histopathology is practised, by streamlining the workflow, increasing efficiency, improving …

[HTML][HTML] Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival

C Joseph, M Alsaleem, N Orah, PL Narasimha… - Breast cancer research …, 2020 - Springer
Purpose MMP9 is a matricellular protein associated with extracellular matrix (ECM)
remodelling, that promotes tumour progression, and modulates the activity of cell adhesion …

[HTML][HTML] Predictors of pathological complete response to neoadjuvant treatment and changes to post-neoadjuvant HER2 status in HER2-positive invasive breast …

A Katayama, IM Miligy, S Shiino, MS Toss, K Eldib… - Modern Pathology, 2021 - Elsevier
The response of human epidermal growth factor receptor2 (HER2)-positive breast cancer
(BC) patients to anti-HER2 targeted therapy is significant. However, the response is not …

Invasion in breast lesions: the role of the epithelial–stroma barrier

EA Rakha, IM Miligy, KL Gorringe, MS Toss… - …, 2018 - Wiley Online Library
Despite the significant biological, behavioural and management differences between ductal
carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many …

Semantic annotation for computational pathology: multidisciplinary experience and best practice recommendations

N Wahab, IM Miligy, K Dodd, H Sahota… - The Journal of …, 2022 - Wiley Online Library
Recent advances in whole‐slide imaging (WSI) technology have led to the development of a
myriad of computer vision and artificial intelligence‐based diagnostic, prognostic, and …

Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer

C Joseph, M Arshad, S Kurozomi, M Althobiti… - Breast Cancer Research …, 2019 - Springer
Purpose CD133/prominin 1 is a cancer stem cell marker associated with cancer progression
and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) …

[HTML][HTML] A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk

S Klimov, IM Miligy, A Gertych, Y Jiang, MS Toss… - Breast Cancer …, 2019 - Springer
Background Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-
detected breast cancers. The overall risk for DCIS patients treated with breast-conserving …

[HTML][HTML] AI-enabled routine H&E image based prognostic marker for early-stage luminal breast cancer

N Wahab, M Toss, IM Miligy, M Jahanifar… - npj Precision …, 2023 - nature.com
Breast cancer (BC) grade is a well-established subjective prognostic indicator of tumour
aggressiveness. Tumour heterogeneity and subjective assessment result in high degree of …

[HTML][HTML] The prognostic significance of immune microenvironment in breast ductal carcinoma in situ

MS Toss, A Abidi, D Lesche, C Joseph… - British journal of …, 2020 - nature.com
Background The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast
ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the …

[HTML][HTML] Retrospective observational study of HER2 immunohistochemistry in borderline breast cancer patients undergoing neoadjuvant therapy, with an emphasis on …

EA Rakha, IM Miligy, CM Quinn, E Provenzano… - British journal of …, 2021 - nature.com
Abstract Background The ASCO/CAP guidance on HER2 testing in breast cancer (BC) has
recently changed. Group 2 tumours with immunohistochemistry score 2+ and HER2/CEP17 …