A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
BJM Braakhuis, MP Tabor, JA Kummer, CR Leemans… - Cancer research, 2003 - AACR
The concept of “field cancerization” was first introduced by Slaughter et al.[D. P, Slaughter et
al., Cancer (Phila.), 6: 963–968, 1953] in 1953 when studying the presence of histologically …
al., Cancer (Phila.), 6: 963–968, 1953] in 1953 when studying the presence of histologically …
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
JMM Walboomers, MV Jacobs… - The Journal of …, 1999 - Wiley Online Library
A recent report that 93 per cent of invasive cervical cancers worldwide contain human
papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration …
papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration …
Notch1 functions as a tumor suppressor in mouse skin
M Nicolas, A Wolfer, K Raj, JA Kummer, P Mill… - Nature …, 2003 - nature.com
Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in
many developmental systems 1, and aberrant Notch signaling is associated with …
many developmental systems 1, and aberrant Notch signaling is associated with …
[HTML][HTML] Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity
H Watanabe, O Gaide, V Pétrilli, F Martinon… - Journal of Investigative …, 2007 - Elsevier
The inflammasome is a cytosolic protein complex regulating the activation of caspase-1,
which cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active form. The …
which cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active form. The …
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response
JA Kummer, R Broekhuizen, H Everett… - … of Histochemistry & …, 2007 - journals.sagepub.com
Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by
mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to …
mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to …
Orphan granzymes find a home
N Bovenschen, JA Kummer - Immunological reviews, 2010 - Wiley Online Library
Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore …
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore …
Performance of immuno–positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in …
PKE Börjesson, YWS Jauw, R Boellaard… - Clinical Cancer …, 2006 - AACR
Purpose: Immuno–positron emission tomography (PET), the combination of PET with
monoclonal antibodies (mAb), is an attractive option to improve tumor detection and to guide …
monoclonal antibodies (mAb), is an attractive option to improve tumor detection and to guide …
Molecular assays for the diagnosis of minimal residual head-and-neck cancer: methods, reliability, pitfalls, and solutions
VMM van Houten, MP Tabor, MWM van den Brekel… - Clinical cancer …, 2000 - AACR
The prognosis of cancer patients is determined by the radicalness of treatment: residual
tumor cells will grow out and develop in manifest local recurrences, regional recurrences …
tumor cells will grow out and develop in manifest local recurrences, regional recurrences …
Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications
MP Tabor, RH Brakenhoff, VMM van Houten… - Clinical Cancer …, 2001 - AACR
Abstract In 1953, Slaughter et al.[DP Slaughter et al., Cancer (Phila.), 6: 963–968, 1953]
proposed the concept of field cancerization in patients with squamous cell carcinoma of the …
proposed the concept of field cancerization in patients with squamous cell carcinoma of the …
The FUTURE trial: a multicenter randomised controlled trial on target biopsy techniques based on magnetic resonance imaging in the diagnosis of prostate cancer in …
O Wegelin, L Exterkate, M van der Leest, JA Kummer… - European urology, 2019 - Elsevier
Background Guidelines advise multiparametric magnetic resonance imaging (mpMRI)
before repeat biopsy in patients with negative systematic biopsy (SB) and a suspicion of …
before repeat biopsy in patients with negative systematic biopsy (SB) and a suspicion of …