The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway is frequently mutated in human cancer. This pathway consists of a small GTP protein …

Objectives To summarize evidence regarding the health outcomes associated with polypharmacy,
defined as number of prescribed medications, in older community‐dwelling persons. …

Methods Prior to the conference, the organizing committee identified topics relevant to the
management of patients with ACLF. A diverse international panel representing multiple …

Background & Aims There are no effective and safe treatments for chronic hepatitis C virus (HCV)
infection of patients who have advanced liver disease. Methods In this phase 2, open-…

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature
evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5…

The ocean plays a critical role in supporting human well-being, from providing food, livelihoods
and recreational opportunities to regulating the global climate. Sustainable management …

The present study was undertaken to assess the utility of the theory of planned behaviour,
using separate measures of the two variables that are considered to comprise the notion of …

Background Patients with ischemic stroke or transient ischemic attack (TIA) are at increased
risk for future cardiovascular events despite current preventive therapies. The identification …

Background As the population that is infected with the hepatitis C virus (HCV) ages, the
number of patients with decompensated cirrhosis is expected to increase. Methods We …