User profiles for "author:J R Mann"
Jeffrey R MannMelbourne Verified email at monash.edu Cited by 10105 |
Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention
AJ Dannenberg, SM Lippman, JR Mann… - Journal of clinical …, 2005 - ascopubs.org
Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …
necessary for the development of therapeutic strategies to prevent cancer …
The role of prostaglandins and other eicosanoids in the gastrointestinal tract
D Wang, JR Mann, RN Dubois - Gastroenterology, 2005 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are generally prescribed to ameliorate
symptoms associated with acute pain and chronic inflammatory diseases such as arthritis …
symptoms associated with acute pain and chronic inflammatory diseases such as arthritis …
Mechanisms of disease: Inflammatory mediators and cancer prevention
JR Mann, MG Backlund, RN DuBois - Nature clinical practice Oncology, 2005 - nature.com
Discovery of molecular pathways critical to carcinogenesis is revolutionizing the treatment
and prevention of cancer. Traditional chemotherapeutic approaches usually cause'global' …
and prevention of cancer. Traditional chemotherapeutic approaches usually cause'global' …
Prevalence and Diversity of Constitutional Mutations in the p53 Gene among 21 Li-Fraumeni Families
JM Birch, AL Hartley, KJ Tricker, J Prosser, A Condie… - Cancer research, 1994 - AACR
The entire coding sequence of the p53 gene was analysed for the presence of mutations in
12 families conforming to a restricted definition of Li-Fraumeni syndrome (classic LFS) and …
12 families conforming to a restricted definition of Li-Fraumeni syndrome (classic LFS) and …
ATRX interacts with H3. 3 in maintaining telomere structural integrity in pluripotent embryonic stem cells
LH Wong, JD McGhie, M Sim, MA Anderson… - Genome …, 2010 - genome.cshlp.org
ATRX (a lpha t halassemia/mental r etardation syndrome X-linked) belongs to the
SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain …
SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain …
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
C Mulle, A Sailer, I Pérez-Otaño, H Dickinson-Anson… - Nature, 1998 - nature.com
Abstract l-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain,
acts on three classes of ionotropic receptors: NMDA (N-methyl-d-aspartate), AMPA (α-amino …
acts on three classes of ionotropic receptors: NMDA (N-methyl-d-aspartate), AMPA (α-amino …
[PDF][PDF] RNA binding antagonizes neurotoxic phase transitions of TDP-43
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
LM Cree, DC Samuels, SC de Sousa Lopes… - Nature …, 2008 - nature.com
Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but
the mechanisms involved are not fully understood. Females harboring a mixture of mutant …
the mechanisms involved are not fully understood. Females harboring a mixture of mutant …
[HTML][HTML] Inner ear defects induced by null mutationof the isk Gene
The isk gene is expressed in many tissues. Pharmacological evidence from the inner ear
suggests that Isk mediates potassium secretion into the endolymph. To examine the …
suggests that Isk mediates potassium secretion into the endolymph. To examine the …
[HTML][HTML] 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
MG Backlund, JR Mann, VR Holla, FG Buchanan… - Journal of Biological …, 2005 - ASBMB
Prostaglandin E 2 (PGE 2) can stimulate tumor progression by modulating several
proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and …
proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and …