Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.
JJ Yang, R Kettritz, RJ Falk, JC Jennette… - The American journal …, 1996 - ncbi.nlm.nih.gov
The pathogenesis of vasculitis associated with anti-neutrophil cytoplasmic antibodies is not
established. The anti-neutrophil cytoplasmic antibody autoanigens proteinase 3 (PR3) and …
established. The anti-neutrophil cytoplasmic antibody autoanigens proteinase 3 (PR3) and …
Anti–LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis
AJ Roth, MC Brown, RN Smith… - Journal of the …, 2012 - journals.lww.com
Abstract Lysosomal membrane protein 2 (LAMP-2) is a target of antineutrophil cytoplasmic
autoantibodies (ANCA) in addition to the more commonly known targets proteinase 3 and …
autoantibodies (ANCA) in addition to the more commonly known targets proteinase 3 and …
Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants
JJ Yang, GA Preston, WF Pendergraft… - The American journal of …, 2001 - Elsevier
The important issue addressed by the studies presented here is the mechanism of
neutrophil-mediated damage to endothelial and epithelial cells during inflammation. Binding …
neutrophil-mediated damage to endothelial and epithelial cells during inflammation. Binding …
Antibodies with dual reactivity to plasminogen and complementary PR3 in PR3-ANCA vasculitis
Patients with inflammatory vascular disease caused by anti-neutrophil cytoplasmic
autoantibodies (ANCA) can harbor antibodies not only to the autoantigen proteinase 3 …
autoantibodies (ANCA) can harbor antibodies not only to the autoantigen proteinase 3 …
Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic …
JJ Yang, WF Pendergraft, DA Alcorta… - Journal of the …, 2004 - journals.lww.com
Granulopoiesis-related genes are distinctively upregulated in peripheral leukocytes of
patients with antineutrophil cytoplasmic autoantibodies (ANCA)-associated …
patients with antineutrophil cytoplasmic autoantibodies (ANCA)-associated …
Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-κB and proapoptotic changes in JNK, ERK …
GA Preston, CS Zarella, WF Pendergraft III… - Journal of the …, 2002 - journals.lww.com
Leukocyte-derived proteases have long been considered simply degradative. However,
emerging data raise possibilities of a complex and specific biologic role for these proteases …
emerging data raise possibilities of a complex and specific biologic role for these proteases …
Microarray studies of gene expression in circulating leukocytes in kidney diseases
D Alcorta, G Preston, W Munger, P Sullivan… - Experimental …, 2002 - karger.com
The molecular characterization of changes in mRNA expression in renal tissue during
disease is hampered by the acquisition of sufficient mRNA to do genomewide expression …
disease is hampered by the acquisition of sufficient mRNA to do genomewide expression …
Understanding the pathogenesis of ANCA: where are we today?
GA Preston, JJ Yang, H Xiao, RJ Falk - Cleveland Clinic journal of …, 2002 - europepmc.org
The role of ANCA, ANCA antigens, endothelial cell damage, genetic and environmental
pressures, and the" activatability" of leukocytes will probably prove to be important variables …
pressures, and the" activatability" of leukocytes will probably prove to be important variables …
[HTML][HTML] Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA)
JJ Yang, GA Preston, DA Alcorta, I Waga, WE Munger… - Kidney international, 2002 - Elsevier
Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic
autoantibodies (ANCA). Background Anti-neutrophil cytoplasmic autoantibodies (ANCA) …
autoantibodies (ANCA). Background Anti-neutrophil cytoplasmic autoantibodies (ANCA) …
Animal models in ANCA-vasculitis
R Kettritz, JJ Yang, K Kinjoh… - Clinical & …, 1995 - academic.oup.com
Animal models in ANCAvasculitis Page 1 12 6th Intemational ANCA Workshop 18 Bach JF.
Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Reviews 1994; 15 …
Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Reviews 1994; 15 …