Microbiological and clinical outcomes of treating non-Mycobacterium avium complex nontuberculous mycobacterial pulmonary disease: a systematic review and meta …
R Diel, F Ringshausen, E Richter, L Welker, J Schmitz… - Chest, 2017 - Elsevier
Background Pulmonary disease caused by nontuberculous mycobacteria (NTM) is steadily
increasing worldwide. Methods A systematic review of non-Mycobacterium avium complex …
increasing worldwide. Methods A systematic review of non-Mycobacterium avium complex …
[PDF][PDF] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
J Schmitz, A Owyang, E Oldham, Y Song, E Murphy… - Immunity, 2005 - cell.com
Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important
functions in host defense, immune regulation, and inflammation. Insight into their biological …
functions in host defense, immune regulation, and inflammation. Insight into their biological …
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
AA Chackerian, ER Oldham, EE Murphy… - The Journal of …, 2007 - journals.aai.org
Abstract IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …
[HTML][HTML] SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
J Schmitz, M Weissenbach, S Haan, PC Heinrich… - Journal of Biological …, 2000 - ASBMB
Interleukin-6 is involved in the regulation of many biological activities such as gene
expression, cell proliferation, and differentiation. The control of the termination of cytokine …
expression, cell proliferation, and differentiation. The control of the termination of cytokine …
[HTML][HTML] SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
U Lehmann, J Schmitz, M Weissenbach… - Journal of Biological …, 2003 - ASBMB
Interleukin-6 (IL-6) activates the Jak/STAT pathway as well as the mitogen-activated protein
kinase cascade. Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has …
kinase cascade. Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has …
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute …
F SCHAPER, C GENDO, M ECK, J SCHMITZ… - Biochemical …, 1998 - portlandpress.com
Stimulation of the interleukin-6 (IL-6) signalling pathway occurs via the IL-6 receptor–
glycoprotein 130 (IL-6R–gp130) receptor complex and results in the regulation of acute …
glycoprotein 130 (IL-6R–gp130) receptor complex and results in the regulation of acute …
Syk inhibitors as treatment for allergic rhinitis
ES Masuda, J Schmitz - Pulmonary pharmacology & therapeutics, 2008 - Elsevier
Allergic rhinitis is characterized by a hypersensitive immune response in the upper airways
to seasonal or perennial allergens leading to episodes of sneezing, itching, runny nose and …
to seasonal or perennial allergens leading to episodes of sneezing, itching, runny nose and …
[HTML][HTML] LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
Recent findings indicate that cytokine signaling can be modulated by other mediators of
simultaneously activated signal transduction pathways. In this study we show that LPS and …
simultaneously activated signal transduction pathways. In this study we show that LPS and …
[HTML][HTML] Efficacy and safety of mirikizumab in a randomized phase 2 study of patients with ulcerative colitis
WJ Sandborn, M Ferrante, BR Bhandari, E Berliba… - Gastroenterology, 2020 - Elsevier
Background & Aims Interleukin 23 contributes to the pathogenesis of ulcerative colitis (UC).
We investigated the effects of mirikizumab, a monoclonal antibody against the p19 subunit of …
We investigated the effects of mirikizumab, a monoclonal antibody against the p19 subunit of …
[HTML][HTML] Expression of suppressors of cytokine signaling during liver regeneration
JS Campbell, L Prichard, F Schaper… - The Journal of …, 2001 - Am Soc Clin Investig
The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial
hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription …
hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription …