Microbiological and clinical outcomes of treating non-Mycobacterium avium complex nontuberculous mycobacterial pulmonary disease: a systematic review and meta …

R Diel, F Ringshausen, E Richter, L Welker, J Schmitz… - Chest, 2017 - Elsevier
Background Pulmonary disease caused by nontuberculous mycobacteria (NTM) is steadily
increasing worldwide. Methods A systematic review of non-Mycobacterium avium complex …

[PDF][PDF] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

J Schmitz, A Owyang, E Oldham, Y Song, E Murphy… - Immunity, 2005 - cell.com
Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important
functions in host defense, immune regulation, and inflammation. Insight into their biological …

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

AA Chackerian, ER Oldham, EE Murphy… - The Journal of …, 2007 - journals.aai.org
Abstract IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …

[HTML][HTML] SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

J Schmitz, M Weissenbach, S Haan, PC Heinrich… - Journal of Biological …, 2000 - ASBMB
Interleukin-6 is involved in the regulation of many biological activities such as gene
expression, cell proliferation, and differentiation. The control of the termination of cytokine …

[HTML][HTML] SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

U Lehmann, J Schmitz, M Weissenbach… - Journal of Biological …, 2003 - ASBMB
Interleukin-6 (IL-6) activates the Jak/STAT pathway as well as the mitogen-activated protein
kinase cascade. Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has …

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute …

F SCHAPER, C GENDO, M ECK, J SCHMITZ… - Biochemical …, 1998 - portlandpress.com
Stimulation of the interleukin-6 (IL-6) signalling pathway occurs via the IL-6 receptor–
glycoprotein 130 (IL-6R–gp130) receptor complex and results in the regulation of acute …

Syk inhibitors as treatment for allergic rhinitis

ES Masuda, J Schmitz - Pulmonary pharmacology & therapeutics, 2008 - Elsevier
Allergic rhinitis is characterized by a hypersensitive immune response in the upper airways
to seasonal or perennial allergens leading to episodes of sneezing, itching, runny nose and …

[HTML][HTML] LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages

JG Bode, A Nimmesgern, J Schmitz, F Schaper… - FEBS letters, 1999 - Elsevier
Recent findings indicate that cytokine signaling can be modulated by other mediators of
simultaneously activated signal transduction pathways. In this study we show that LPS and …

[HTML][HTML] Efficacy and safety of mirikizumab in a randomized phase 2 study of patients with ulcerative colitis

WJ Sandborn, M Ferrante, BR Bhandari, E Berliba… - Gastroenterology, 2020 - Elsevier
Background & Aims Interleukin 23 contributes to the pathogenesis of ulcerative colitis (UC).
We investigated the effects of mirikizumab, a monoclonal antibody against the p19 subunit of …

[HTML][HTML] Expression of suppressors of cytokine signaling during liver regeneration

JS Campbell, L Prichard, F Schaper… - The Journal of …, 2001 - Am Soc Clin Investig
The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial
hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription …