Prognostic role of tumor infiltrating lymphocytes in EBV positive and EBV negative nasopharyngeal carcinoma

ML Ooft, JA van Ipenburg, WW Braunius, CI Zuur… - Oral oncology, 2017 - Elsevier
Abstract Objectives Tumor infiltrating lymphocytes (TILs) correlate with both better and worse
prognosis in solid tumors. As therapeutic modalities for nasopharyngeal carcinoma (NPC) …

Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma

EC Coopmans, SWF Van Meyel… - European Journal of …, 2019 - academic.oup.com
Prolactinomas are the most commonly encountered pituitary adenomas in the clinical
setting. While most can be controlled by dopamine agonists, a subset of prolactinomas are …

Prognostic role of tumour-associated macrophages and regulatory T cells in EBV-positive and EBV-negative nasopharyngeal carcinoma

ML Ooft, JA van Ipenburg, ME Sanders… - Journal of clinical …, 2018 - jcp.bmj.com
Aims Tumour-associated macrophages (TAMs) and regulatory T cells (Tregs) form a special
niche supporting tumour progression, and both correlate with worse survival in head and …

[HTML][HTML] Molecular Genetics of Conjunctival Melanoma and Prognostic Value of TERT Promoter Mutation Analysis

NM van Poppelen, JA van Ipenburg… - International Journal of …, 2021 - mdpi.com
The aim of this study was exploration of the genetic background of conjunctival melanoma
(CM) and correlation with recurrent and metastatic disease. Twenty-eight CM from the …

[HTML][HTML] Predicting biochemical recurrence of prostate cancer with artificial intelligence

H Pinckaers, J van Ipenburg, J Melamed… - Communications …, 2022 - nature.com
Background The first sign of metastatic prostate cancer after radical prostatectomy is rising
PSA levels in the blood, termed biochemical recurrence. The prediction of recurrence relies …

[HTML][HTML] Early on-treatment circulating tumor DNA measurements and response to immune checkpoint inhibitors in advanced urothelial cancer

SH Tolmeijer, S van Wilpe, MJ Geerlings… - European Urology …, 2024 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) can induce durable disease
control in metastatic urothelial cancer (mUC), but only 20–25% of patients respond. Early …

[HTML][HTML] ATRX Loss in the Development and Prognosis of Conjunctival Melanoma

JA van Ipenburg, QCC van den Bosch… - International Journal of …, 2023 - mdpi.com
Metastatic disease is linked to TERT promoter mutations in conjunctival melanomas (CM).
Both TERT promoter and ATRX mutations are associated with faulty telomere maintenance …

[HTML][HTML] Chemokine receptor expression pattern correlates to progression of conjunctival melanocytic lesions

JA van Ipenburg, NE de Waard… - … & visual science, 2019 - tvst.arvojournals.org
Purpose: Chemokines play a role in the progression and metastatic spread of both
cutaneous and uveal melanomas. The aim of this study was to examine the prognostic value …

Molecular profile of nasopharyngeal carcinoma: analysing tumour suppressor gene promoter hypermethylation by multiplex ligation-dependent probe amplification

ML Ooft, J van Ipenburg, R van Loo… - Journal of clinical …, 2018 - jcp.bmj.com
Aims To assess differences in methylation profiles, and thus pathogenesis, between Epstein-
Barr virus (EBV)-positive and negative nasopharyngeal carcinomas (NPCs). Also, promoter …

MicroRNA profiling in benign and malignant conjunctival melanocytic lesions

JA van Ipenburg, AJM Gillis, LCJ Dorssers… - …, 2020 - aaojournal.org
Conjunctival melanoma is a rare tumor with an incidence of 0.2 to 0.8 cases per 1 million
people, although the incidence is increasing. Local recurrences and metastases are …