Purpose Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase gene
have recently been described in a subset of non–small-cell lung cancers (NSCLCs) …

Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype with
an obscure etiology. In this study, we sought to describe its unique histopathologic features …

Purpose: Salivary duct carcinomas (SDC) are a rare and aggressive subtype of salivary
gland cancers for which cytotoxic chemotherapy has limited efficacy. We investigated …

Progressive meningiomas that have failed surgery and radiation have a poor prognosis and
no standard therapy. While meningiomas are more common in females overall, progressive …

The molecular events in chordoma pathogenesis have not been fully delineated, particularly
with respect to copy number changes. Understanding copy number alterations in chordoma …

Aggressive neurosurgical resection to achieve sustained local control is essential for
prolonging survival in patients with lower-grade glioma. However, progression in many of …

Purpose Targeted therapy is the cornerstone of treatment of advanced EGFR-mutant non–
small-cell lung cancer (NSCLC). Next-generation sequencing (NGS), the preferred method …

The use of liquid biopsies to identify driver mutations in patients with solid tumors holds
great promise for performing targeted therapy selection, monitoring disease progression …

Purpose It is now recognized that Crohn's disease (CD), similar to ulcerative colitis (UC),
carries an up to 20-fold higher cancer risk, and the development of colorectal carcinoma …

The recent description of a new X chromosome tumor suppressor gene, WTX, that is
commonly inactivated in Wilms' tumor prompted us to examine the possible involvement of …