Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …

Methamphetamine is a drug that is significantly abused worldwide. Although long–lasting
depletion of dopamine and other dopamine nerve terminal markers has been reported in …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development. The current model of …

A recent demonstration of markedly reduced (‐50%) activity of cytochrome oxidase (CO;
complex 4), the terminal enzyme of the mitochondrial enzyme transport chain, in platelets of …

Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing
(RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in
patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor …

Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …

Importance Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain
poor. Advances in next-generation sequencing provide a route to therapeutic approaches …

We integrated clinical, genomic, and transcriptomic data from 224 primaries and 95
metastases from 289 patients to characterize progression of pancreatic ductal …

Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in …