With advancing technology and the consequent shift towards an increasing application of
molecular genetic techniques (eg, microarrays, next-generation sequencing) with the …

Abstract The European Myeloma Network has organized two workshops on fluorescence in
situ hybridization in multiple myeloma. The first aimed to identify specific indications and …

A standardized nomenclature is critical for the accurate and consistent description of
genomic changes as identified by karyotyping, fluorescence in situ hybridization and …

Acute lymphoblastic leukemia (ALL) is a malignancy that can be subdivided into distinct
entities based on clinical, immunophenotypic and genomic features, including mutations …

Abstract Optical Genome Mapping (OGM) is rapidly emerging as an exciting cytogenomic
technology both for research and clinical purposes. In the last 2 years alone, multiple studies …

Translocations involving MYC are rare in chronic lymphocytic leukemia (CLL), and up to
now, their prognostic significance remains unclear. We report the characteristics of 21 …

We have completed a long-range restriction map of the terminal region of the short arm of
human chromosome 16 (16p13. 3) by physically linking a distal genetic locus (a-globin) with …

Genetic profiling is important for disease evaluation and prediction of prognosis or
responsiveness to therapy in neoplasia. Microarray technologies, including array …

Background: Microdeletions at 17q21. 31 have recently been shown to cause a novel
syndrome. Here we identify the reciprocal 17q21. 31 duplication syndrome in 4 patients …

Summary The PRDM16 (1p36) gene is rearranged in acute myeloid leukaemia (AML) and
myelodysplastic syndrome (MDS) with t (1; 3)(p36; q21), sharing characteristics with AML …