Purpose.—To develop a guideline to improve the accuracy of immunohistochemical (IHC)
estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the …

The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century,
yet recent data have revealed that many ligands can differentially activate signaling …

“Suffering so great as I underwent cannot be expressed in words... but the blank whirlwind of
emotion, the horror of great darkness, and the sense of desertion by God and man, which …

Random number generators: good ones are hard to find Page 1 COMPUTING PRACTICES
Edgar H. Sibley Panel Editor Practical and theoretical issues are presented concerning the …

1. Introduction. Ill-posed problems in partial differential equations are those in which the
solution depends uniquely but not continuously on the data. The Cauchy problem for elliptic …

We present new and general numerical methods for dealing with problems whose solutions
develop sharp transition layers or “near-shocks”. These methods allow many nodes …

Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …

Most verification is concerned with finding incorrect code. Instead, this view looks at the
probability that the code will fail if it is faulty. The authors present the benefits of their …

We can live with many of the uncertainties of big data for now, with the hope that its benefits
will outweigh its harms, but we shouldn't blind ourselves to the possible irreversibility of …

Clearly, there are several important advantages for employees and employers when
employees bring their own devices to work. But there are also significant concerns about …