Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting
from knockouts of these genes in mice have provided tremendous insight into gene function …

Abstract The European Nucleotide Archive (ENA; http://www. ebi. ac. uk/ena) is Europe's
primary nucleotide-sequence repository. The ENA consists of three main databases: the …

As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

Ecology is often said to lack general theories sufficiently predictive for applications. Here, we
examine the concept of a periodic table of niches and feasibility of niche classification …

Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have
thus far been disappointing owing to a lack of robust stratification methods. Whole-genome …

Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates
remain less than 15%. A lack of experimental models has hampered progress. We have …

The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of
the brain metabolome and its changes during diseases or aging remain poorly understood …

The role of sex in biomedical studies has often been overlooked, despite evidence of
sexually dimorphic effects in some biological studies. Here, we used high-throughput …

Although next-generation sequencing has revolutionized the ability to associate variants
with human diseases, diagnostic rates and development of new therapies are still limited by …

Porcine epidemic diarrhea virus (PEDV) is associated with clinical diarrhea in naïve swine of
all ages. This report describes timing of antibody generation and disease progression …