Hox genes and segmentation of the vertebrate hindbrain
S Tümpel, LM Wiedemann, R Krumlauf - Current topics in developmental …, 2009 - Elsevier
In the vertebrate central nervous system, the hindbrain is an important center for
coordinating motor activity, posture, equilibrium, sleep patterns, and essential unconscious …
coordinating motor activity, posture, equilibrium, sleep patterns, and essential unconscious …
Identification of the haematopoietic stem cell niche and control of the niche size
J Zhang, C Niu, L Ye, H Huang, X He, WG Tong, J Ross… - Nature, 2003 - nature.com
Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-
renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche' …
renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche' …
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling
In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis
syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The …
syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The …
[HTML][HTML] Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
J Zhang, JC Grindley, T Yin, S Jayasinghe, XC He… - Nature, 2006 - nature.com
Haematopoietic stem cells (HSCs) must achieve a balance between quiescence and
activation that fulfils immediate demands for haematopoiesis without compromising long …
activation that fulfils immediate demands for haematopoiesis without compromising long …
PTEN-deficient intestinal stem cells initiate intestinal polyposis
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase
in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread …
in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread …
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional …
P Wang, C Lin, ER Smith, H Guo… - … and cellular biology, 2009 - Taylor & Francis
A common landmark of activated genes is the presence of trimethylation on lysine 4 of
histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is …
histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is …
[HTML][HTML] The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution
The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing
vertebrate evolution. To enable more informed analyses, we developed a new assembly of …
vertebrate evolution. To enable more informed analyses, we developed a new assembly of …
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
A Hermans, N Heisterkamp, M von Lindern, S van Baal… - Cell, 1987 - cell.com
Summary The Philadelphia (Ph) chromosome, the product of t (9: 22), is the cytogenetic
hallmark of chronic myelogenous leukemia. The c-abl oncogene on chromosome 9 is …
hallmark of chronic myelogenous leukemia. The c-abl oncogene on chromosome 9 is …
A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia
LC Chan, KK Karhi, SI Rayter, N Heisterkamp… - Nature, 1987 - nature.com
Abstract The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia
are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated bcr 1 …
are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated bcr 1 …