User profiles for "author:Lorella Pascolo"
 | Lorella PascoloIRCCS Burlo Garofolo Verified email at burlo.trieste.it Cited by 3134 |
Molecular basis of bilirubin-induced neurotoxicity
JD Ostrow, L Pascolo, D Brites, C Tiribelli - Trends in molecular medicine, 2004 - cell.com
Unconjugated bilirubin (UCB), at slightly elevated unbound concentrations, is toxic to
astrocytes and neurons, damaging mitochondria (causing impaired energy metabolism and …
astrocytes and neurons, damaging mitochondria (causing impaired energy metabolism and …
[HTML][HTML] Renin angiotensin system, COVID-19 and male fertility: any risk for conceiving?
The current knowledge concerning the connection between severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and the renin–angiotensin system (RAS) system in …
syndrome coronavirus 2 (SARS-CoV-2) and the renin–angiotensin system (RAS) system in …
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
F Gennuso, C Fernetti, C Tirolo… - Proceedings of the …, 2004 - National Acad Sciences
Unconjugated bilirubin (UCB) causes encephalopathy in severely jaundiced neonates by
damaging astrocytes and neurons. Astrocytes, which help defend the brain against cytotoxic …
damaging astrocytes and neurons. Astrocytes, which help defend the brain against cytotoxic …
[HTML][HTML] Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro
DJ Ostrow, L Pascolo, C Tiribelli - Pediatric research, 2003 - nature.com
Most studies of the cellular toxicity of unconjugated bilirubin (UCB) have been performed at
concentrations of unbound UCB (BF) that exceed those in the plasma of neonates with …
concentrations of unbound UCB (BF) that exceed those in the plasma of neonates with …
[HTML][HTML] The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy
L Pascolo, A Gianoncelli, G Schneider, M Salomé… - Scientific reports, 2013 - nature.com
Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer
but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to …
but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to …
[HTML][HTML] SARS-CoV-2 and the next generations: which impact on reproductive tissues?
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) is a severe global pandemic, affecting mostly the …
syndrome–coronavirus 2 (SARS-CoV-2) is a severe global pandemic, affecting mostly the …
[HTML][HTML] Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: results of a novel ultrafiltration method
RA Weisiger, JD Ostrow, RK Koehler… - Journal of Biological …, 2001 - ASBMB
Albumin binding is a crucial determinant of bilirubin clearance in health and bilirubin toxicity
in certain disease states. However, prior attempts to measure the affinity of albumin for …
in certain disease states. However, prior attempts to measure the affinity of albumin for …
Cellular distribution and degradation of cobalt ferrite nanoparticles in Balb/3T3 mouse fibroblasts
The effect of the concentration of cobalt ferrite (CoFe2O4) nanoparticles (NPs) on their
intracellular location and distribution has been explored by synchrotron radiation X-ray and …
intracellular location and distribution has been explored by synchrotron radiation X-ray and …
Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells
L Pascolo, C Fernetti, D Pirulli, S Crovella… - Biochemical and …, 2003 - Elsevier
The placenta is a multifunctional organ that protects the fetus from toxic compounds and the
MRPs contribute to this function. The expression of MRP1, MRP2, MRP3, and MRP5 was …
MRPs contribute to this function. The expression of MRP1, MRP2, MRP3, and MRP5 was …
Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents
L Pascolo, F Cupelli, PL Anelli, V Lorusso… - Biochemical and …, 1999 - Elsevier
The mechanisms were investigated for the hepatic transport of 4 different gadolinium
complexes used as contrast agents for magnetic resonance imaging (MRI). In basolateral rat …
complexes used as contrast agents for magnetic resonance imaging (MRI). In basolateral rat …