Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of
chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) …

Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although
several protein-coding genes are altered, expression signature and importance of …

We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3,
and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate …

Mature B-cell lymphomas with both BCL2 and MYC translocations are known as “double hit”
lymphomas. These lymphomas are aggressive and show high proliferation rate due to the …

The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates
in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with …

Mounting evidence suggests that dynamic interactions between a tumor and its
microenvironment play a critical role in tumor development, cell-cycle progression, and …

Follicular dendritic cells (FDCs), an essential component of the lymph node
microenvironment, regulate and support B-lymphocyte differentiation, survival, and …

Concordant activation of MYC and BCL-2 oncoproteins in double-hit lymphoma (DHL)
results in aggressive disease that is refractory to treatment. By integrating activity-based …

Drug-tolerant" persister" tumor cells underlie emergence of drug-resistant clones and
contribute to relapse and disease progression. Here we report that resistance to the BCL-2 …

A dynamic interaction occurs between the lymphoma cell and its microenvironment, with
each profoundly influencing the behavior of the other. Here, using a clonogenic coculture …