Discovery of 4-[3-(trans-3-Dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]- (4S)-oxazolidin-2-one (4991W93), a 5HT1B/1D Receptor Partial Agonist and a Potent …

KS Jandu, V Barrett, M Brockwell… - Journal of medicinal …, 2001 - ACS Publications
Utilizing a pharmacophoric model of binding of 3-(2-aminoethyl) indoles to 5HT1B/1D
receptors, we identified the 3-aminocyclobutyl group as a potential ethylamine isostere. A …

[HTML][HTML] Confirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle

YM Brockwell, TP Elliott, GR Anderson… - International Journal for …, 2014 - Elsevier
Triclabendazole (TCBZ) is the drug of choice for Fasciola hepatica control and reports of F.
hepatica resistant to this drug from a wide range of geographic regions are very concerning …

Comparative kinetics of serological and coproantigen ELISA and faecal egg count in cattle experimentally infected with Fasciola hepatica and following treatment with …

YM Brockwell, TW Spithill, GR Anderson, V Grillo… - Veterinary …, 2013 - Elsevier
Three methods of diagnosing Fasciola hepatica (F. hepatica) infection (a coproantigen
ELISA, Bio-X Diagnostics, Belgium, Faecal Egg Count (FEC), and a serum IgG ELISA, Bio-X …

[BOOK][B] The van Eycks and their Art

WHJ Weale, MW Brockwell - 1912 - books.google.com
It is no easy task for me to address to the general reader a few prefatory remarks on the
monumental work which Mr. Weale published some four years ago through Mr. John Lane …

Inexpensive and practical sealed drift-tube neutron detector

Z Wang, CL Morris, MF Makela, JD Bacon… - Nuclear Instruments and …, 2009 - Elsevier
The design, construction, and performance of a type of sealed 3He drift tubes for neutron
detection are presented. Because the 3He pressure is in the 25–300mbar range, the …

Development of a novel series of trialkoxyaryl derivatives as specific and competitive antagonists of platelet activating factor.

DA Sawyer, RM Beams, GJ Blackwell… - Journal of medicinal …, 1995 - europepmc.org
The synthesis and structure-activity relationship (SAR) analysis of a novel series of
trialkoxyaryl derivatives, as specific and competitive inhibitors of platelet activating factor …

Heterocyclic prostaglandin analogues. Part 3. The relationship of configuration to biological activity for some hydantoin prostaglandin analogues

MA Brockwell, AG Caldwell, N Whittaker… - Journal of the Chemical …, 1981 - pubs.rsc.org
The enantiomers of the two diastereoisomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-
hydroxypropyl) hydantoin have been synthesised. Potent inhibition of platelet aggregation in …

Experience of changing between signal and Bactec 9240 blood culture systems in a children's hospital.

J Gray, M Brockwell, I Das - Journal of clinical pathology, 1998 - jcp.bmj.com
AIM: To compare experience of positive blood cultures in successive years before and after
changing from Signal (Unipath) to Bactec 9240 (Becton Dickinson) blood culture systems …

Effects of a commercial dose of L‐tryptophan on plasma tryptophan concentrations and behaviour in horses

GK Noble, YM Brockwell, KJ Munn… - Equine Veterinary …, 2008 - Wiley Online Library
Reasons for performing the study: L‐tryptophan is a common ingredient in equine calmative
products, but its effectiveness has not been demonstrated in horses. Hypothesis: To …

A double-helix neutron detector using micron-size 10B powder

Z Wang, CL Morris, JD Bacon, MI Brockwell… - Nuclear Instruments and …, 2014 - Elsevier
A double-helix electrode configuration is combined with a 10 B powder coating technique to
build large-area (9 in.× 36 in., or about 23 cm by 91 cm) neutron detectors. The neutron …