User profiles for "author:M Jeffers"

Matthew Jeffers

University of Ottawa
Verified email at uottawa.ca
Cited by 1242

Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis

M Jeffers, S Rong, GF Vande Woude - Journal of Molecular Medicine, 1996 - Springer
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing
the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety …

[HTML][HTML] Is environmental enrichment ready for clinical application in human post-stroke rehabilitation?

MW McDonald, KS Hayward… - Frontiers in behavioral …, 2018 - frontiersin.org
Environmental enrichment (EE) has been widely used as a means to enhance brain
plasticity mechanisms (eg, increased dendritic branching, synaptogenesis, etc.) and improve …

[HTML][HTML] Exercise and environmental enrichment as enablers of task-specific neuroplasticity and stroke recovery

J Livingston-Thomas, P Nelson, S Karthikeyan… - …, 2016 - Elsevier
Improved stroke care has resulted in greater survival, but> 50% of patients have chronic
disabilities and 33% are institutionalized. While stroke rehabilitation is helpful, recovery is …

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

N Khan, M Jeffers, S Kumar, C Hackett… - Biochemical …, 2008 - portlandpress.com
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …

PDGF-D, a new protease-activated growth factor

WJ LaRochelle, M Jeffers, WF McDonald… - Nature cell …, 2001 - nature.com
Platelet-derived growth factor (PDGF) has been directly implicated in developmental and
physiological processes 1, 2, 3, 4, 5, as well as in human cancer, fibrotic diseases and …

Activating mutations for the met tyrosine kinase receptor in human cancer

M Jeffers, L Schmidt, N Nakaigawa… - Proceedings of the …, 1997 - National Acad Sciences
Recently, mutations in the Met tyrosine kinase receptor have been identified in both
hereditary and sporadic forms of papillary renal carcinoma. We have introduced the …

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

GH Xiao, M Jeffers, A Bellacosa… - Proceedings of the …, 2001 - National Acad Sciences
Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-
Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We …

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a …

…, A Wagner, D Laurent, M Teufel, M Jeffers… - The Lancet …, 2015 - thelancet.com
Background Tumour mutational status is an important determinant of the response of
metastatic colorectal cancer to targeted treatments. However, the genotype of the tissue …

[HTML][HTML] Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study

…, A Frost, M Büchert, O Christensen, M Jeffers… - British journal of …, 2012 - nature.com
Background: In a phase I dose-escalation study, regorafenib demonstrated tolerability and
antitumour activity in solid tumour patients. The study was expanded to focus on patients …

Met and hepatocyte growth factor/scatter factor expression in human gliomas

S Koochekpour, M Jeffers, S Rulong, G Taylor… - Cancer research, 1997 - AACR
Using double immunofluorescence staining and quantitative confocal laser scan
microscopy, we show that the intensity of hepatocyte growth factor/scatter factor (HGF/SF) …