Gene transcription and ubiquitin-mediated proteolysis are two processes that have
seemingly nothing in common: transcription is the first step in the life of any protein and …

Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Space agencies have announced plans for human missions to the Moon to prepare for
Mars. However, the space environment presents stressors that include radiation …

Many transcription factors, particularly those involved in the control of cell growth, are
unstable proteins destroyed by ubiquitin-mediated proteolysis. In a previous study of …

The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the
role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian …

Despite their apparent diversity, many problems in the analysis of high-throughput
sequencing data are merely special cases of two general problems, signal detection and …

Abstract Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-
cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in …

Promyelocytic leukaemia (PML) nuclear bodies are present in most mammalian cell nuclei.
PML bodies are disrupted by PML retinoic acid receptor alpha (RARα) oncoproteins in acute …

We report here that the prototypical yeast transcription factor Gal4 undergoes two distinct
modes of ubiquitin-mediated proteolysis: one that occurs independent of transcription and …

The limited number of in vivo germ cells poses an impediment to genome-wide studies.
Here, we applied a small-scale chromatin immunoprecipitation sequencing (ChIP-seq) …