The focus of high-throughput drug discovery has progressed through the genome and the
transcriptome and is now moving towards more difficult problems in assessing the proteome …

Oestradiol can stimulate osteoblast activity. Osteoblast function is thought to be regulated by
nitric oxide (NO). We hypothesised that the effect of 17β-oestradiol (17β-E2) on osteoblast …

An acute inflammatory response is mounted in response to a stimulus such as tissue
damage or the presence of an invading pathogen (1). If this stimulus cannot be removed …

Objective The inflammatory mediator substance P (SP) acts principally through the
neurokinin (NK 1) receptor. We assessed the influence of SP on production of NO and its …

The differential ferrioxamine test (Fielding, J. Clin. Pathol., 1965, 18, 88) was applied to 4
groups of subjects, 31 healthy men, 37 patients with unequi-vocal iron-deficiency anaemia …

The differential ferrioxamine test measures the amount of body iron as ferrioxamine (Fv)
chelated by a standard dose of desferrioxamine. Five patients with untreated, uncomplicated …

Previous work suggested that during the catabolism of haemoglobin a physico-chemical
form of iron was released which was more readily chelatable by desferrioxamine than …

Publisher Summary Nitric oxide (NO) is a gas radical that is enzymatically produced by the
oxidation and cleavage of one of the terminal nitrogen atoms of the amino acid L-arginine …

The biotin-binding capacity in the wells of a streptavidin-coated PCR plate were quantified
by means of a fluorescence intensity assay utilising biotin-labelled fluorescein and a …

The Jirgl flocculation test has been compared with the combination of the thymol reactions
and serum alkaline phosphatase determination recommended by Maclagan in the …