Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible …

Two recurrent mutations, K27M and G34R/V, within histone variant H3. 3 were recently
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …

Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of …

The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

Infant high-grade gliomas appear clinically distinct from their counterparts in older children,
indicating that histopathologic grading may not accurately reflect the biology of these tumors …