Helicobacter pylori: perspectives and time trends

P Malfertheiner, A Link, M Selgrad - Nature reviews Gastroenterology & …, 2014 - nature.com
The discovery of Helicobacter pylori three decades ago is a modern medical success story. It
markedly changed our understanding of the pathophysiology of gastroduodenal diseases …

Gastric cancer: clinical aspects, epidemiology and molecular background

J Bornschein, T Rokkas, M Selgrad… - Helicobacter, 2011 - Wiley Online Library
The validity and usefulness of the 7th edition of the UICC tumor node metastasis
classification in the context of clinical management of gastric cancer are discussed. The …

Treatment of Helicobacter pylori

M Selgrad, P Malfertheiner - Current Opinion in Gastroenterology, 2011 - journals.lww.com
Treatment of H. pylori infection is challenged by a dramatic fall in eradication rates all over
the world. Newer regimens have been introduced including sequential, quadruple therapies …

Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM–p53 cascade in colon cancer cell lines

L Fini, E Hotchkiss, V Fogliano, G Graziani… - …, 2008 - academic.oup.com
The Mediterranean diet is rich in extra virgin olive oil (EVOO) and associated with a lower
incidence of colorectal cancer. EVOO contains phenolic extracts with potential …

H. pylori Infection Is a Key Risk Factor for Proximal Gastric Cancer

J Bornschein, M Selgrad, M Warnecke… - Digestive diseases and …, 2010 - Springer
Background Despite evidence for the association of distal gastric cancer (GC) with the H.
pylori infection, relevance of the infection for proximal GC is uncertain. Aims We analysed …

[HTML][HTML] Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection

M Selgrad, I Tammer, C Langner… - World journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To assess whether antibiotic resistance varies between the antrum and corpus of the
stomach of patients that are either Helicobacter pylori (H. pylori) therapy-naive or pre …

[HTML][HTML] Serological assessment of gastric mucosal atrophy in gastric cancer

J Bornschein, M Selgrad, T Wex, D Kuester… - BMC …, 2012 - Springer
Background Non-invasive tools for gastric cancer screening and diagnosis are lacking.
Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and …

[HTML][HTML] Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells

L Fini, M Selgrad, V Fogliano, G Graziani… - The Journal of …, 2007 - Elsevier
The CpG island methylator phenotype is characterized by DNA hypermethylation in the
promoters of tumor suppressor genes with silencing of transcription. Hypermethylation of the …

Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies

M Selgrad, J Meile, J Bornschein… - European Journal of …, 2013 - journals.lww.com
Antibiotic susceptibility of Helicobacter pylori in central... : European Journal of
Gastroenterology & Hepatology Antibiotic susceptibility of Helicobacter pylori in central …

Efficacy, immunogenicity, and safety of a parenteral vaccine against Helicobacter pylori in healthy volunteers challenged with a Cag-positive strain: a randomised …

P Malfertheiner, M Selgrad, T Wex, B Romi… - The Lancet …, 2018 - thelancet.com
Background Intramuscular immunisation with a vaccine composed of three recombinant
Helicobacter pylori antigens—vacuolating cytotoxin A (VacA), cytotoxin-associated antigen …