Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning

C Weis, A Cuénod, B Rieck, O Dubuis, S Graf… - Nature Medicine, 2022 - nature.com
Early use of effective antimicrobial treatments is critical for the outcome of infections and the
prevention of treatment resistance. Antimicrobial resistance testing enables the selection of …

Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis

…, K Jaton, GE Pfyffer, S Borrell, O Dubuis… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Bacterial factors may contribute to the global emergence and spread of drug-resistant
tuberculosis (TB). Only a few studies have reported on the interactions between different …

[HTML][HTML] Air-conditioner cooling towers as complex reservoirs and continuous source of Legionella pneumophila infection evidenced by a genomic analysis study in …

…, S Gautsch, R Spieler-Denz, O Dubuis… - …, 2019 - eurosurveillance.org
Introduction Water supply and air-conditioner cooling towers (ACCT) are potential sources of
Legionella pneumophila infection in people. During outbreaks, traditional typing methods …

[HTML][HTML] “Pseudo-Beijing”: Evidence for Convergent Evolution in the Direct Repeat Region of Mycobacterium tuberculosis

L Fenner, B Malla, B Ninet, O Dubuis, D Stucki… - PloS one, 2011 - journals.plos.org
Background Mycobacterium tuberculosis has a global population structure consisting of six
main phylogenetic lineages associated with specific geographic regions and human …

Clinical outcome in pneumococcal meningitis correlates with CSF lipoteichoic acid concentrations

O Schneider, U Michel, G Zysk, O Dubuis, R Nau - Neurology, 1999 - AAN Enterprises
Article abstract Lipoteichoic and teichoic acids are components of the cell wall of
Streptococcus pneumoniae. A recently developed enzyme immunoassay was used in …

[HTML][HTML] Colistin resistance in Gram-negative bacteria analysed by five phenotypic assays and inference of the underlying genomic mechanisms

…, HMB Seth-Smith, N Joosse, C Lang, O Dubuis… - BMC microbiology, 2021 - Springer
Background Colistin is used against multi-drug resistant pathogens, yet resistance emerges
through dissemination of plasmid-mediated genes (mcr) or chromosomal mutation of genes …

[HTML][HTML] Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten …

…, R Frei, R Hertel, M Dolina, O Petrini, O Dubuis… - Clinical microbiology …, 2018 - Elsevier
Objectives Echinocandins represent the first-line treatment of candidaemia. Acquired
echinocandin resistance is mainly observed among Candida albicans and Candida glabrata …

[HTML][HTML] Characterising the epidemic spread of influenza A/H3N2 within a city through phylogenetics

…, M Syedbasha, D Lang, RA Neher, O Dubuis… - PLoS …, 2020 - journals.plos.org
Infecting large portions of the global population, seasonal influenza is a major burden on
societies around the globe. While the global source sink dynamics of the different seasonal …

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in an urban area

…, M Siegemund, H Pargger, D Ciardo, O Dubuis… - Virus …, 2022 - academic.oup.com
Transmission chains within small urban areas (accommodating∼ 30 per cent of the
European population) greatly contribute to case burden and economic impact during the …

A critical assessment of the prognostic value of HIV-1 RNA levels and CD4+ cell counts in HIV-infected patients

…, TV Perneger, B Hirschel, O Dubuis… - Archives of internal …, 1998 - jamanetwork.com
Objective To determine to what extent human immunodeficiency type 1 (HIV-1) RNA levels
and CD4+ cell counts predict clinical outcomes in a general HIV-1–infected population …