The generation of cortical projection neurons relies on the coordination of radial migration
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …

Background Patients who undergo total hip replacement have a high risk of thromboembolic
complications. Recombinant hirudin (desirudin), a specific inhibitor of thrombin, represents a …

The lls1 (lethal leaf spot1) locus of maize is defined by a recessive mutation characterized
by the initiation, in a developmentally programmed manner, of necrotic lesions that expand …

Lysine acetylation is a post-translational modification that critically regulates gene
transcription by targeting histones as well as a variety of transcription factors in the nucleus …

To assess the safety of a conservative approach to fibro-adenoma of the breast we
prospectively studied 321 women with this clinical diagnosis, and performed aspiration …

Reprogramming of mRNA translation has a key role in cancer development and drug
resistance. However, the molecular mechanisms that are involved in this process remain …

Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a
severe neurodevelopmental disease with complex clinical characteristics. Elongator was …

The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-
related progenitors. At the onset of corticogenesis, the first-born progenitors are apical …

Translational control of protein synthesis supports tumor development and progression to
metastasis. Wobble tRNA modifications are required during translation elongation and …

Background The likelihood of restenosis is a major limitation of coronary angioplasty. We
studied whether hirudin, a highly selective inhibitor of thrombin with irreversible effects …