User profiles for "author:P J Little"

Prof. Peter J. Little AM

School of Pharmacy, The University of Queensland
Verified email at uq.edu.au
Cited by 13163

Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies

S Xu, I Ilyas, PJ Little, H Li, D Kamato, X Zheng… - Pharmacological …, 2021 - ASPET
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Insulin resistance and atherosclerosis

J Nigro, N Osman, AM Dart, PJ Little - Endocrine reviews, 2006 - academic.oup.com
The epidemic of obesity in the developed world over the last two decades is driving a large
increase in type 2 diabetes and consequentially setting the scene for an impending wave of …

[HTML][HTML] FOXO signaling pathways as therapeutic targets in cancer

M Farhan, H Wang, U Gaur, PJ Little, J Xu… - International journal of …, 2017 - ncbi.nlm.nih.gov
Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs

BR Martin, DR Compton, BF Thomas… - Pharmacology …, 1991 - Elsevier
Numerous cannabinoids have been synthesized that are extremely potent in all of the
behavioral assays conducted in our laboratory. An important feature in increasing potency …

Cardiovascular actions and therapeutic potential of tanshinone IIA

S Gao, Z Liu, H Li, PJ Little, P Liu, S Xu - Atherosclerosis, 2012 - Elsevier
Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the
Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian …

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

S Xu, S Ogura, J Chen, PJ Little, J Moss… - Cellular and Molecular Life …, 2013 - Springer
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation

D Kamato, ML Burch, TJ Piva, HB Rezaei, MA Rostam… - Cellular signalling, 2013 - Elsevier
Transforming growth factor-β (TGF-β) is a secreted homodimeric protein that plays an
important role in regulating various cellular responses including cell proliferation and …

Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.

PJ Little, DR Compton, MR Johnson, LS Melvin… - … of Pharmacology and …, 1988 - ASPET
The pharmacological effects of three stereoisomeric pairs of structurally novel cannabinoids
were tested after iv administration in mice for depression of spontaneous activity and the …

Zinc and cardiovascular disease

PJ Little, R Bhattacharya, AE Moreyra, IL Korichneva - Nutrition, 2010 - Elsevier
Zinc is a vital element in maintaining the normal structure and physiology of cells. The fact
that it has an important role in states of cardiovascular diseases has been studied and …

Differential effects of ethanol in adolescent and adult rats

PJ Little, CM Kuhn, WA Wilson… - Alcoholism: Clinical …, 1996 - Wiley Online Library
Alcohol use in children and adolescents is widespread. However, very little is known about
the effects of alcohol exposure during this period of postnatal development. The goal of the …