Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play
essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are …

Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse
cells. Breast cancer cells with a CD44+/CD24-phenotype have been suggested to have …

Pathway-specific therapy is the future of cancer management. The oncogenic
phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; …

Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it
is rarely curable. Cell‐free circulating tumor DNA (ct DNA) contains tumor‐specific …

Background The CD44 cell adhesion molecule is aberrantly expressed in many breast
tumors and has been implicated in the metastatic process as well as in the putative cancer …

Lipophilic statins purportedly exert anti-tumoral effects on breast cancer by decreasing
proliferation and increasing apoptosis. HMG-CoA reductase (HMGCR), the rate-limiting …

Previous in vitro studies have implied that the Wnt-5a gene plays a role as a tumor
suppressor. To explore the clinical relevance of this concept, 96 primary invasive breast …

Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of
histopathological subtypes, different genetic characteristics, and frequent intratumoral …

Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with
estrogen receptor (ERα)–positive breast carcinoma but are not indicated for persons with …

BACKGROUND: To decrease recurrences in non–muscle-invasive bladder cancer (NMIBC),
the European Association of Urology (EAU) guidelines recommend immediate, intravesical …