Estrogen and progesterone receptors: from molecular structures to clinical targets
Research involving estrogen and progesterone receptors (ER and PR) have greatly
contributed to our understanding of cell signaling and transcriptional regulation. In addition …
contributed to our understanding of cell signaling and transcriptional regulation. In addition …
[HTML][HTML] Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
KB Chiappinelli, PL Strissel, A Desrichard, H Li… - Cell, 2015 - cell.com
We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …
Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
R Strick, PL Strissel, S Borgers… - Proceedings of the …, 2000 - National Acad Sciences
Chromosomal translocations involving the MLL gene occur in about 80% of infant leukemia.
In the search for possible agents inducing infant leukemia, we identified bioflavonoids …
In the search for possible agents inducing infant leukemia, we identified bioflavonoids …
Clinical aspects of Mayer–Rokitansky–Kuester–Hauser syndrome: recommendations for clinical diagnosis and staging
P Oppelt, SP Renner, A Kellermann… - Human …, 2006 - academic.oup.com
Abstract BACKGROUND: The Mayer–Rokitansky–Kuester–Hauser (MRKH) syndrome is a
malformation of the female genitals (occurring in one in 4000 female live births) as a result of …
malformation of the female genitals (occurring in one in 4000 female live births) as a result of …
[PDF][PDF] Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer
MJ Topper, M Vaz, KB Chiappinelli, CEDS Shields… - Cell, 2017 - cell.com
Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with
histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune …
histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune …
[HTML][HTML] Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection
MG Schrauder, R Strick, R Schulz-Wendtland… - PloS one, 2012 - journals.plos.org
Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules
with relevance as regulators of gene expression thereby affecting crucial processes in …
with relevance as regulators of gene expression thereby affecting crucial processes in …
[HTML][HTML] The VCUAM (Vagina Cervix Uterus Adnex–associated Malformation) Classification: a new classification for genital malformations
OBJECTIVE: With an incidence of up to 5% in the general population, genital malformations
are a frequent clinical occurrence. However, using the existing published classifications of …
are a frequent clinical occurrence. However, using the existing published classifications of …
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
ML Stone, KB Chiappinelli, H Li… - Proceedings of the …, 2017 - National Acad Sciences
Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet
need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an …
need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an …
Cation–chromatin binding as shown by ion microscopy is essential for the structural integrity of chromosomes
R Strick, PL Strissel, K Gavrilov… - The Journal of cell biology, 2001 - rupress.org
Mammalian interphase and mitotic cells were analyzed for their cation composition using a
three-dimensional high resolution scanning ion microprobe. This instrument maps the …
three-dimensional high resolution scanning ion microprobe. This instrument maps the …
Impaired cytotrophoblast cell–cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction
M Langbein, R Strick, PL Strissel, N Vogt… - Molecular …, 2008 - Wiley Online Library
Abstract Preeclampsia (PE), Hemolysis Elevated Liver Enzymes and Low Platelets (HELLP)‐
syndrome, and intrauterine growth restriction (IUGR) are associated with abnormal …
syndrome, and intrauterine growth restriction (IUGR) are associated with abnormal …