Age being a risk factor for Parkinson's disease, assessment of age-related changes in the
human substantia nigra may elucidate its pathogenesis. Increase in Marinesco bodies, α …

Background Potential biomarkers to aid diagnosis and therapy need to be identified for
Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The …

Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with
unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6 …

Background Non-cell autonomous toxicity is one of the potential mechanisms implicated in
the etiopathogenesis of amyotrophic lateral sclerosis (ALS). However, the exact role of glial …

We have earlier reported that intrathecal injection of cerebrospinal fluid (CSF) from sporadic
Amyotrophic Lateral Sclerosis patients (ALS-CSF) into neonatal rats and supplementation of …

Background: The survival of motor neurons is dependent upon neurotrophic factors both
during childhood and adolescence and during adult life. In disease conditions, such as in …

We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral
Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism …

Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …

Background Microglial cell-associated neuroinflammation is considered as a potential
contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis. However, the …

Vascular endothelial growth factor (VEGF), the well-known angiogenic factor is both
neurotrophic and neuroprotective. Altered VEGF signalling is implicated in the pathogenesis …