It is intuitive to speculate that nutrient availability may influence differentiation of mammalian
cells. Nonetheless, a comprehensive complement of the molecular determinants involved in …

Sir2 is a NAD+-dependent histone deacetylase that controls gene silencing, cell cycle, DNA
damage repair, and life span. Prompted by the observation that the [NAD+]/[NADH] ratio is …

We used expression profiling to define the pathophysiological cascades involved in the
progression of two muscular dystrophies with known primary biochemical defects …

Most prior studies of primary diagnosis in surgical pathology using whole slide imaging
(WSI) versus microscopy have focused on specific organ systems or included relatively few …

Mutations of lamin A/C (LMNA) cause a wide range of human disorders, including progeria,
lipodystrophy, neuropathies and autosomal dominant Emery–Dreifuss muscular dystrophy …

MyoD regulates skeletal myogenesis. Since proteins associated with MyoD exert regulatory
functions, their identification is expected to contribute important insights into the mechanisms …

Fusion of undifferentiated myoblasts into multinucleated myotubes is a prerequisite for
developmental myogenesis and postnatal muscle growth. We report that deacetylase …

Emery–Dreifuss muscular dystrophy (EDMD1) is caused by mutations in either the X-linked
gene emerin (EMD) or the autosomal lamin A/C (LMNA) gene. Here, we describe the …

Embryonic myogenesis involves the staged induction of myogenic regulatory factors and
positional cues that dictate cell determination, proliferation, and differentiation into adult …

We present an assessment of the complete transcriptome of human skeletal muscle in
Duchenne muscular dystrophy patient muscle and non-dystrophic controls (36 RNAs …