User profiles for "author:R A Scolyer"
Richard A ScolyerMelanoma Institute Australia, The University of Sydney, Royal Prince Alfred Hospital Verified email at sswahs.nsw.gov.au Cited by 85973 |
Cutaneous melanoma
Episodic exposure of fair-skinned individuals to intense sunlight is thought to be responsible
for the steadily increasing melanoma incidence worldwide over recent decades. Rarely …
for the steadily increasing melanoma incidence worldwide over recent decades. Rarely …
Resistance to PD1/PDL1 checkpoint inhibition
For the first time in decades, patients with difficult-to-treat cancers such as advanced stage
metastatic melanoma are being offered a glimpse of hope in the form of immunotherapies …
metastatic melanoma are being offered a glimpse of hope in the form of immunotherapies …
The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary …
DE Elder, BC Bastian, IA Cree… - … of pathology & …, 2020 - meridian.allenpress.com
Context.—There have been major advances in the understanding of melanoma since the
last revision of the World Health Organization (WHO) classification in 2006. Objective.—To …
last revision of the World Health Organization (WHO) classification in 2006. Objective.—To …
Melanoma staging: evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual
Answer questions and earn CME/CNE To update the melanoma staging system of the
American Joint Committee on Cancer (AJCC) a large database was assembled comprising> …
American Joint Committee on Cancer (AJCC) a large database was assembled comprising> …
Whole-genome landscapes of major melanoma subtypes
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal
body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout …
body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout …
Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma
Purpose To assess the frequency and type of oncogenic BRAF mutations in metastatic
melanoma and correlate BRAF status with clinicopathologic features and outcome. Patients …
melanoma and correlate BRAF status with clinicopathologic features and outcome. Patients …
[HTML][HTML] Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance
The development of acquired drug resistance hampers the long-term success of B-RAF
inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as …
inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as …
[HTML][HTML] Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical
for various biological and pathological processes. 5-mC can be converted to 5 …
for various biological and pathological processes. 5-mC can be converted to 5 …
Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial
JJ Luke, P Rutkowski, P Queirolo, M Del Vecchio… - The Lancet, 2022 - thelancet.com
Background Pembrolizumab prolongs progression-free and overall survival among patients
with advanced melanoma and recurrence-free survival in resected stage III disease …
with advanced melanoma and recurrence-free survival in resected stage III disease …
Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study
Background Nivolumab monotherapy and combination nivolumab plus ipilimumab increase
proportions of patients achieving a response and survival versus ipilimumab in patients with …
proportions of patients achieving a response and survival versus ipilimumab in patients with …