User profiles for "author:R Kirsch"

Robert Kirsch

Professor and Chair of Biomedical Engineering, Case Western Reserve University
Verified email at case.edu
Cited by 6198

[HTML][HTML] Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016

A Lugli, R Kirsch, Y Ajioka, F Bosman, G Cathomas… - Modern pathology, 2017 - Elsevier
Tumor budding is a well-established independent prognostic factor in colorectal cancer but
a standardized method for its assessment has been lacking. The primary aim of the …

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue

…, T Poutahidis, SE Erdman, R Kirsch… - Molecular cancer …, 2012 - AACR
Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …

[HTML][HTML] Tumor budding in colorectal carcinoma: time to take notice

B Mitrovic, DF Schaeffer, RH Riddell, R Kirsch - Modern Pathology, 2012 - Elsevier
Tumor 'budding', loosely defined by the presence of individual cells and small clusters of
tumor cells at the invasive front of carcinomas, has received much recent attention …

The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest

D Szklarczyk, R Kirsch, M Koutrouli… - Nucleic acids …, 2023 - academic.oup.com
Much of the complexity within cells arises from functional and regulatory interactions among
proteins. The core of these interactions is increasingly known, but novel interactions …

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

…, AL Gable, KC Nastou, D Lyon, R Kirsch… - Nucleic acids …, 2021 - academic.oup.com
Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …

[PDF][PDF] Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology

…, A Schwegmann, M Radwanska, M Leeto, R Kirsch… - Immunity, 2004 - cell.com
Abstract Macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysM Cre IL-
4Rα−/flox) were generated to understand the role of IL-4/IL-13 responsive myeloid cells …

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration

AB Ajiboye, FR Willett, DR Young, WD Memberg… - The Lancet, 2017 - thelancet.com
Background People with chronic tetraplegia, due to high-cervical spinal cord injury, can
regain limb movements through coordinated electrical stimulation of peripheral muscles and …

Computer determination of the constituent structure of biological images

RA Kirsch - Computers and biomedical research, 1971 - Elsevier
A class of algorithms is described which enables computer quantized images to be
decomposed into constituent reflecting the structure of the images. This decomposition is …

[PDF][PDF] Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients

RP Myers, G Pomier‐Layrargues, R Kirsch… - …, 2012 - Wiley Online Library
Failure of liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) and
unreliable results occur in≈ 5% and 15% of patients, respectively, mainly due to obesity. In …

An update of the phase III trial comparing whole pelvic to prostate only radiotherapy and neoadjuvant to adjuvant total androgen suppression: updated analysis of …

…, M DeSilvio, M Roach III, V Uhl, R Kirsch… - International Journal of …, 2007 - Elsevier
PURPOSE: This trial was designed to test the hypothesis that total androgen suppression
and whole pelvic radiotherapy (WPRT) followed by a prostate boost improves progression …