The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
D Egan, R O'kennedy, E Moran, D Cox… - Drug metabolism …, 1990 - Taylor & Francis
Coumarin was first isolated in 1822 and synthesized in 1868. It was banned by the Food and
Drug Administration in the 1950s, being classified as a category 1 carcinogen and …
Drug Administration in the 1950s, being classified as a category 1 carcinogen and …
Anticoagulants in the treatment of cancer
P Hilgard, RD Thornes - European Journal of Cancer (1965), 1976 - Elsevier
A PATHOGENIC, role of blood coagulation in the haematogenous spread of cancer was
suggested by the microcinematographic investigations of S. Wood Jr. using the Hopkins …
suggested by the microcinematographic investigations of S. Wood Jr. using the Hopkins …
Treatment with coumarin to prevent or delay recurrence of malignant melanoma
RD Thornes, L Daly, G Lynch, B Breslin… - Journal of cancer …, 1994 - Springer
Abstract Both coumarin (1, 2-benzopyrone) and warfarin (4-hydroxycoumarin) have been
shown to prevent the recurrence of malignant melanoma. Their action is macrophage …
shown to prevent the recurrence of malignant melanoma. Their action is macrophage …
The rarity of liver toxicity in patients treated with coumarin (1, 2-benzopyrone)
D Cox, R O'kennedy, RD Thornes - Human toxicology, 1989 - journals.sagepub.com
1 Two thousand, one hundred and seventy-three patients with cancer or chronic infections
were treated with coumarin in a clinical trial. 2 0.37% of these patients developed elevated …
were treated with coumarin in a clinical trial. 2 0.37% of these patients developed elevated …
Adjuvant therapy of cancer via the cellular immune mechanism or fibrin by induced fibrinolysis and oral anticoagulants
RD Thornes - Cancer, 1975 - Wiley Online Library
The value of the oral anticoagulant warfarin sodium and fibrinolytic agents is discussed in
relation to cancer surgery. A controlled trial of 128 patients showed that in a variety of …
relation to cancer surgery. A controlled trial of 128 patients showed that in a variety of …
A critical analysis of the use of sialic acid determination in the diagnosis of malignancy
R O'Kennedy, G Berns, E Moran, H Smyth, K Carroll… - Cancer letters, 1991 - Elsevier
The measurement of serum sialic acid in sera from individuals with leukemia, breast,
gastrointestinal, lung and bladder cancers, brucellosis and manic depression is described …
gastrointestinal, lung and bladder cancers, brucellosis and manic depression is described …
The enhancing influence of proteolysis on E rosette forming lymphocytes (T cells) in vivo and in vitro
PD Holland, O Browne, RD Thornes - British Journal of Cancer, 1975 - nature.com
The T lymphocytes populations of 22 young healthy adults, 21 healthy middle aged and
older blood donors, 35 non-pregnant women of child bearing age and 14 patients with …
older blood donors, 35 non-pregnant women of child bearing age and 14 patients with …
Unblocking or activation of the cellular immune mechanism by induced proteolysis in patients with cancer
RD Thornes - The Lancet, 1974 - Elsevier
The induction of enhanced proteolysis (fibrinolysis) by streptokinase or'Brinase'(protease i)
activated the cellular immune mechanism in forty patients with cancer who were previously …
activated the cellular immune mechanism in forty patients with cancer who were previously …
Direct determination of 7-hydroxycoumarin and 7-hydroxycoumarin-glucuronide in urine by using capillary electrophoresis
DP Bogan, RD Thornes, M Tegtmeier, EA Schafer… - Analyst, 1996 - pubs.rsc.org
A method has been developed for the direct determination of 7-hydroxycoumarin (7HC) and
7-hydroxycoumaringlucuronide (7HCG) in urine without sample clean-up. Separation was …
7-hydroxycoumaringlucuronide (7HCG) in urine without sample clean-up. Separation was …
Inhibition of antiplasmin, and fibrinolytic effect of protease in patients with cancer
ET O'Brien, RD Thornes, D O'Brien, B Hogan - The Lancet, 1968 - Elsevier
Protease I (a fibrinolytic enzyme from Aspergillus oryzœ) inhibited thromboplastin and
antiplasmin activity in vitro; and the antiplasmin inhibitory activity is potentiated in vitro by …
antiplasmin activity in vitro; and the antiplasmin inhibitory activity is potentiated in vitro by …