Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Bacteria causing chronic infections predominately grow as surface-attached, sessile
communities known as biofilms. Biofilm-related infections including cystic fibrosis lung …

Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas
aeruginosa causes persistent morbidity and mortality in cystic fibrosis (CF). Chronic P …

Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application
to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with …

Streptococcus pneumoniae accounts for a significant global burden of morbidity and
mortality and biofilm development is increasingly recognised as important for colonization …

The impact of immunosuppression on interferon-γ release assays and novel cytokine
biomarkers of TB infection, mycobacteria-specific IL-2, IP-10 and TNF-α responses was …

Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon
mutant collection for this important clinical pathogen. Here, we validate a model system to …

Objectives The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D ('DiEthylAmin-
Cephalosporin-3′-Diazeniumdiolate') has been shown to initiate the dispersal of biofilms …

The current methods for diagnosis of acute and chronic infections are complex and skill-
intensive. For complex clinical biofilm infections, it can take days from collecting and …

Background Chronic rhinosinusitis (CRS) with nasal polyps is a common chronic condition.
The exact cause of nasal polyps remains unknown. Recently, we made the novel …