Cyclin D as a therapeutic target in cancer
EA Musgrove, CE Caldon, J Barraclough… - Nature Reviews …, 2011 - nature.com
Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these …
and is a biomarker of cancer phenotype and disease progression. The ability of these …
Biological determinants of endocrine resistance in breast cancer
EA Musgrove, RL Sutherland - Nature Reviews Cancer, 2009 - nature.com
Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …
Progestin regulation of cellular proliferation
CL Clarke, RL Sutherland - Endocrine reviews, 1990 - academic.oup.com
I. Introduction T HE control of cellular proliferation is known to involve a delicate balance
between the effects of different regulatory molecules including hormones and growth factors …
between the effects of different regulatory molecules including hormones and growth factors …
Genomic analyses identify molecular subtypes of pancreatic cancer
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
JB Welsh, LM Sapinoso, SG Kern… - Proceedings of the …, 2003 - National Acad Sciences
Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory
autocrine and paracrine signals, involving overexpression of secreted peptide growth …
autocrine and paracrine signals, involving overexpression of secreted peptide growth …
Androgen receptor inhibits estrogen receptor-α activity and is prognostic in breast cancer
There is emerging evidence that the balance between estrogen receptor-α (ERα) and
androgen receptor (AR) signaling is a critical determinant of growth in the normal and …
androgen receptor (AR) signaling is a critical determinant of growth in the normal and …
[HTML][HTML] Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin …
OWJ Prall, B Sarcevic, EA Musgrove, CKW Watts… - Journal of Biological …, 1997 - ASBMB
Estrogens induce cell proliferation in target tissues by stimulating progression through G 1
phase of the cell cycle, but the underlying molecular targets remain undefined. To determine …
phase of the cell cycle, but the underlying molecular targets remain undefined. To determine …
Prolactin controls mammary gland development via direct and indirect mechanisms
The inactivation of the prolactin receptor gene by homologous recombination has made it
possible to investigate the role of prolactin signaling in mammary gland development …
possible to investigate the role of prolactin signaling in mammary gland development …
Frequent loss of estrogen receptor-β expression in prostate cancer
LG Horvath, SM Henshall, CS Lee, DR Head, DI Quinn… - Cancer research, 2001 - AACR
The role of estrogen and its receptors in the etiology and progression of prostate cancer
(PC) is poorly understood. In normal and malignant human prostate, estrogen receptor-α is …
(PC) is poorly understood. In normal and malignant human prostate, estrogen receptor-α is …
A preoperative nomogram identifying decreased risk of positive pelvic lymph nodes in patients with prostate cancer
I Cagiannos, P Karakiewicz, JA Eastham… - The Journal of …, 2003 - auajournals.org
Purpose: We developed a preoperative nomogram for prediction of lymph node metastases
in patients with clinically localized prostate cancer. Materials and Methods: The study was a …
in patients with clinically localized prostate cancer. Materials and Methods: The study was a …