Bone marrow niches in haematological malignancies
Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres
In bone marrow biopsies, stromal structural fibres are detected by reticulin and trichrome
stains, routine stains performed on bone marrow biopsy specimens in diagnostic …
stains, routine stains performed on bone marrow biopsy specimens in diagnostic …
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
DP Steensma, R Bejar, S Jaiswal… - Blood, The Journal …, 2015 - ashpublications.org
Recent genetic analyses of large populations have revealed that somatic mutations in
hematopoietic cells leading to clonal expansion are commonly acquired during human …
hematopoietic cells leading to clonal expansion are commonly acquired during human …
The International Consensus Classification of acute myeloid leukemia
OK Weinberg, A Porwit, A Orazi, RP Hasserjian… - Virchows Archiv, 2023 - Springer
Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with
rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification …
rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification …
Molecular international prognostic scoring system for myelodysplastic syndromes
E Bernard, H Tuechler, PL Greenberg… - NEJM …, 2022 - evidence.nejm.org
Background Risk stratification and therapeutic decision-making for myelodysplastic
syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS …
syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS …
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
MHGP Raaijmakers, S Mukherjee, S Guo, S Zhang… - Nature, 2010 - nature.com
Mesenchymal cells contribute to the 'stroma'of most normal and malignant tissues, with
specific mesenchymal cells participating in the regulatory niches of stem cells. By examining …
specific mesenchymal cells participating in the regulatory niches of stem cells. By examining …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
H Döhner, AH Wei, FR Appelbaum… - Blood, The Journal …, 2022 - ashpublications.org
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
WS Pear, JC Aster, ML Scott, RP Hasserjian… - The Journal of …, 1996 - rupress.org
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions
and is found in organisms ranging from Drosophila to humans. A human homologue of …
and is found in organisms ranging from Drosophila to humans. A human homologue of …
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Abstract Tumor protein p53 (TP53) is the most frequently mutated gene in cancer,. In
patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high …
patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high …