Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …

Lactate generated from pyruvate fuels production of intracellular NAD+ as an end result of
the glycolytic process in tumors. Elevated lactate concentration represents a good indicator …

Survivin, a small member of the inhibitors of the apoptosis protein family, is highly
deregulated in cancer. It is weakly expressed in normal tissues but very strongly expressed …

The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates
caspase-1 and mediates the release of interleukin 1β (IL-1β) and IL-18. Whether NLRP3 can …

Intestinal microbiota have been proposed to induce commensal-specific memory T cells that
cross-react with tumor-associated antigens. We identified major histocompatibility complex …

Host immunity controls the development of colorectal cancer, and chemotherapy used to
treat colorectal cancer is likely to recruit the host immune system at some level. Athough …

Simple Summary Alternative splicing is one of the most fabulous and important mechanism
in the cell. Alternative splicing is capable of generating many proteins from a single gene …

The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and
out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel …

Several approaches to manipulate the gut microbiome for improving the activity of cancer
immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …