BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair

G Sessa, B Gómez‐González, S Silva… - The EMBO …, 2021 - embopress.org
The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential
for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA …

[HTML][HTML] Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

Å Ehlén, C Martin, S Miron, M Julien, FX Theillet… - Nature …, 2020 - nature.com
The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity
through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo …

Frequency of microsatellite instability (MSI) in upper tract urothelial carcinoma: comparison of the Bethesda panel and the Idylla MSI assay in a consecutively collected …

F Kullmann, PL Strissel, R Strick, R Stoehr… - Journal of Clinical …, 2023 - jcp.bmj.com
Aims Upper tract urothelial carcinoma (UTUC) is a rare malignancy with a poor prognosis
which occurs sporadically or in few cases results from a genetic disorder called Lynch …

The mutational landscape of skull base and spinal chordomas and the identification of potential prognostic and theranostic biomarkers

T Passeri, T Gutman, A Hamza, H Adle-Biassette… - Journal of …, 2023 - thejns.org
OBJECTIVE Chordomas are rare bone neoplasms characterized by a high recurrence rate
and no benefit from any approved medical treatment to date. However, the investigation of …

[HTML][HTML] Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies

H Lang, C Béraud, L Cabel, J Fontugne… - Frontiers in …, 2022 - frontiersin.org
Background Muscle-invasive bladder cancer (MIBC) and upper urinary tract urothelial
carcinoma (UTUC) are molecularly heterogeneous. Despite chemotherapies …

[HTML][HTML] Donor/recipient origin of lung cancer after lung transplantation by DNA short tandem repeat analysis

J De Wolf, E Robin, A Vallee, J Cohen… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Background Lung cancer is more common in posttransplant recipients than in the general
population. The objective of this study was to examine the chimerism donor/recipient cell …

[PDF][PDF] Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

VB Theillet, G Sessa, R Beaurepere, V Boucherit… - researchgate.net
The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity
through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by …

The Mutational Landscape of Skull-Base and Spinal Chordomas Identifies Potential Prognostic and Theranostic Biomarkers

T Passeri, T Gutman, A Hamza… - … Surgery Part B: Skull …, 2023 - thieme-connect.com
Background: Chordomas are rare bone neoplasms characterized by a high recurrence rate
and not benefitting from, to date, any approved medical treatment. However, the …

[CITATION][C] BRCA2 promotes R-loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination

G Sessa, B Gomez-Gonzalez… - EMBO …, 2021 - … ST, HOBOKEN 07030-5774, NJ USA