Fungal heat-shock proteins in human disease

JP Burnie, TL Carter, SJ Hodgetts… - FEMS microbiology …, 2006 - academic.oup.com
Heat-shock proteins (hsps) have been identified as molecular chaperones conserved
between microbes and man and grouped by their molecular mass and high degree of amino …

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

RC Matthews, G Rigg, S Hodgetts… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Mycograb (Neu Tec Pharma plc) is a human genetically recombinant antibody
against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with …

Recombinant antibodies: a natural partner in combinatorial antifungal therapy

RC Matthews, JP Burnie - Vaccine, 2004 - Elsevier
Monotherapy, in the form of amphotericin B or one of its liposomal derivatives, is the usual
treatment for invasive fungal infections, due to lack of a safe, effective combination of …

Pathogenicity determinants of Candida albicans: potential targets for immunotherapy?

RC Matthews - Microbiology, 1994 - microbiologyresearch.org
Since the early 1960s Candida albicans has emerged from being an infrequent pathogen to
become one of the commonest agents of nosocomial infection. In a national surveillance …

Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans

RC Matthews, JP Burnie… - Journal of Clinical …, 1987 - Am Soc Microbiol
Candidal antigens were isolated by affinity chromatography from the sera of patients with
disseminated Candida albicans infections. The immunodominant 47-kilodalton (kDa) …

Evaluation of Mycograb®, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill …

L Nooney, RC Matthews, JP Burnie - Diagnostic microbiology and infectious …, 2005 - Elsevier
This article reported the identification of heat shock protein 90 (hsp90) homologues by
immunoblot in Cryptococcus neoformans. Mycograb®, a genetically recombinant antibody …

Identification of an Immunodominant ABC Transporter in Methicillin-Resistant Staphylococcus aureusInfections

JP Burnie, RC Matthews, T Carter… - Infection and …, 2000 - Am Soc Microbiol
Immunoblotting sera from 26 patients with septicemia due to an epidemic strain of methicillin-
resistant Staphylococcus aureus (EMRSA-15), 6 of whom died, revealed an …

Heat shock protein 88 and Aspergillus infection

JP Burnie, RC Matthews - Journal of clinical microbiology, 1991 - Am Soc Microbiol
Immunoblotting was used to dissect the antibody responses in the sera of 50 patients with
proven invasive aspergillosis, 28 patients with suspected invasive aspergillosis, 35 patients …

Candida albicans HSP 90: link between protective and auto immunity

RC Matthews - Journal of medical microbiology, 1992 - microbiologyresearch.org
Heat shock proteins (HSP) are thought to play a role in the aetiology of autoimmune
diseases, but are also common targets for the immune response to many infections. Patients …

Role of immunoblotting in the diagnosis of culture negative and enterococcal endocarditis.

JP Burnie, M Holland, RC Matthews… - Journal of clinical …, 1987 - jcp.bmj.com
Serum samples from patients with endocarditis and septicaemia due to Enterococcus
faecalis, Enterococcus faecium, Streptococcus bovis, and Streptococcus sanguis were …