Adrenal hypoplasia is a rare, life-threatening congenital disorder. Here we define a new
form of syndromic adrenal hypoplasia, which we propose to term MIRAGE (myelodysplasia …

Abnormalities in WNT signaling are implicated in a broad range of developmental
anomalies and also in tumorigenesis. Here we demonstrate that germline mutations in WTX …

The initial development of diffuse gastric cancer (DGC) is poorly understood. The study of E-
cadherin (CDH1) germ line mutation carriers predisposed to DGC provides a rare …

Tumorigenesis is an important problem that needs to be addressed in the field of human
stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI) …

Background Variations in the international incidence of Wilms' tumour might be due to
genetic factors. The maternal insulin-like growth factor 2 gene (IGF2) is imprinted in normal …

Perilobar (PLNR) and intralobar nephrogenic rests (ILNR) are distinct precursor lesions of
Wilms tumors that have different structural, clinical, genetic, and epidemiologic features …

Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare
germline mutations, the characterisation of which has refined our understanding of …

Background: Intralobar nephrogenic rests (ILNRs) are precursor lesions for Wilms tumours
and are associated with WT1 gene mutations. ILNR-associated Wilms tumours have a co …

We report on a triploid infant who survived for 46 days. She had severe intrauterine growth
retardation, relative macrocephaly, and a small, noncystic placenta, which are …

The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent
stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant …